Barrett MO - Search Results

1

Quantification of Gi-mediated inhibition of adenylyl cyclase activity reveals that UDP is a potent agonist of the human P2Y14 receptor.

Carter RL, Fricks IP, Barrett MO, Burianek LE, Zhou Y, Ko H, Das A, Jacobson KA, Lazarowski ER, Harden TK. Carter RL, et al. Among authors: barrett mo. Mol Pharmacol. 2009 Dec;76(6):1341-8. doi: 10.1124/mol.109.058578. Epub 2009 Sep 16. Mol Pharmacol. 2009. PMID: 19759354 Free PMC article.

2

A selective high-affinity antagonist of the P2Y14 receptor inhibits UDP-glucose-stimulated chemotaxis of human neutrophils.

Barrett MO, Sesma JI, Ball CB, Jayasekara PS, Jacobson KA, Lazarowski ER, Harden TK. Barrett MO, et al. Mol Pharmacol. 2013 Jul;84(1):41-9. doi: 10.1124/mol.113.085654. Epub 2013 Apr 16. Mol Pharmacol. 2013. PMID: 23592514 Free PMC article.

3

Human P2Y(14) receptor agonists: truncation of the hexose moiety of uridine-5'-diphosphoglucose and its replacement with alkyl and aryl groups.

Das A, Ko H, Burianek LE, Barrett MO, Harden TK, Jacobson KA. Das A, et al. Among authors: barrett mo. J Med Chem. 2010 Jan 14;53(1):471-80. doi: 10.1021/jm901432g. J Med Chem. 2010. PMID: 19902968 Free PMC article.

4

Small molecule inhibitors of phospholipase C from a novel high-throughput screen.

Huang W, Barrett M, Hajicek N, Hicks S, Harden TK, Sondek J, Zhang Q. Huang W, et al. J Biol Chem. 2013 Feb 22;288(8):5840-8. doi: 10.1074/jbc.M112.422501. Epub 2013 Jan 7. J Biol Chem. 2013. PMID: 23297405 Free PMC article.

5

Polyamidoamine (PAMAM) dendrimer conjugates of "clickable" agonists of the A3 adenosine receptor and coactivation of the P2Y14 receptor by a tethered nucleotide.

Tosh DK, Yoo LS, Chinn M, Hong K, Kilbey SM 2nd, Barrett MO, Fricks IP, Harden TK, Gao ZG, Jacobson KA. Tosh DK, et al. Among authors: barrett mo. Bioconjug Chem. 2010 Feb 17;21(2):372-84. doi: 10.1021/bc900473v. Bioconjug Chem. 2010. PMID: 20121074 Free PMC article.

6

Synthesis of extended uridine phosphonates derived from an allosteric P2Y2 receptor ligand.

Song L, Risseeuw MD, Karalic I, Barrett MO, Brown KA, Harden TK, Van Calenbergh S. Song L, et al. Among authors: barrett mo. Molecules. 2014 Apr 4;19(4):4313-25. doi: 10.3390/molecules19044313. Molecules. 2014. PMID: 24714193 Free PMC article.

7

Fluorescent phosphatidylinositol 4,5-bisphosphate derivatives with modified 6-hydroxy group as novel substrates for phospholipase C.

Wang X, Barrett M, Sondek J, Harden TK, Zhang Q. Wang X, et al. Biochemistry. 2012 Jul 3;51(26):5300-6. doi: 10.1021/bi300637h. Epub 2012 Jun 22. Biochemistry. 2012. PMID: 22703043 Free PMC article.

8

Pyrimidine ribonucleotides with enhanced selectivity as P2Y(6) receptor agonists: novel 4-alkyloxyimino, (S)-methanocarba, and 5'-triphosphate gamma-ester modifications.

Maruoka H, Barrett MO, Ko H, Tosh DK, Melman A, Burianek LE, Balasubramanian R, Berk B, Costanzi S, Harden TK, Jacobson KA. Maruoka H, et al. Among authors: barrett mo. J Med Chem. 2010 Jun 10;53(11):4488-501. doi: 10.1021/jm100287t. J Med Chem. 2010. PMID: 20446735 Free PMC article.

9

4-Alkyloxyimino derivatives of uridine-5'-triphosphate: distal modification of potent agonists as a strategy for molecular probes of P2Y2, P2Y4, and P2Y6 receptors.

Jayasekara PS, Barrett MO, Ball CB, Brown KA, Hammes E, Balasubramanian R, Harden TK, Jacobson KA. Jayasekara PS, et al. Among authors: barrett mo. J Med Chem. 2014 May 8;57(9):3874-83. doi: 10.1021/jm500367e. Epub 2014 Apr 18. J Med Chem. 2014. PMID: 24712832 Free PMC article.

10

Pyrimidine nucleotides with 4-alkyloxyimino and terminal tetraphosphate δ-ester modifications as selective agonists of the P2Y(4) receptor.

Maruoka H, Jayasekara MP, Barrett MO, Franklin DA, de Castro S, Kim N, Costanzi S, Harden TK, Jacobson KA. Maruoka H, et al. Among authors: barrett mo. J Med Chem. 2011 Jun 23;54(12):4018-33. doi: 10.1021/jm101591j. Epub 2011 May 20. J Med Chem. 2011. PMID: 21528910 Free PMC article.

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