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Page 1
Treatment with a soluble receptor for activin improves bone mass and structure in the axial and appendicular skeleton of female cynomolgus macaques (Macaca fascicularis).
Fajardo RJ, Manoharan RK, Pearsall RS, Davies MV, Marvell T, Monnell TE, Ucran JA, Pearsall AE, Khanzode D, Kumar R, Underwood KW, Roberts B, Seehra J, Bouxsein ML. Fajardo RJ, et al. Among authors: pearsall ae, pearsall rs. Bone. 2010 Jan;46(1):64-71. doi: 10.1016/j.bone.2009.09.018. Epub 2009 Sep 23. Bone. 2010. PMID: 19781677
A soluble activin type IIA receptor induces bone formation and improves skeletal integrity.
Pearsall RS, Canalis E, Cornwall-Brady M, Underwood KW, Haigis B, Ucran J, Kumar R, Pobre E, Grinberg A, Werner ED, Glatt V, Stadmeyer L, Smith D, Seehra J, Bouxsein ML. Pearsall RS, et al. Proc Natl Acad Sci U S A. 2008 May 13;105(19):7082-7. doi: 10.1073/pnas.0711263105. Epub 2008 May 6. Proc Natl Acad Sci U S A. 2008. PMID: 18460605 Free PMC article.
Characterization of the ligand binding functionality of the extracellular domain of activin receptor type IIb.
Sako D, Grinberg AV, Liu J, Davies MV, Castonguay R, Maniatis S, Andreucci AJ, Pobre EG, Tomkinson KN, Monnell TE, Ucran JA, Martinez-Hackert E, Pearsall RS, Underwood KW, Seehra J, Kumar R. Sako D, et al. Among authors: pearsall rs. J Biol Chem. 2010 Jul 2;285(27):21037-48. doi: 10.1074/jbc.M110.114959. Epub 2010 Apr 12. J Biol Chem. 2010. PMID: 20385559 Free PMC article.
ALK1-Fc inhibits multiple mediators of angiogenesis and suppresses tumor growth.
Mitchell D, Pobre EG, Mulivor AW, Grinberg AV, Castonguay R, Monnell TE, Solban N, Ucran JA, Pearsall RS, Underwood KW, Seehra J, Kumar R. Mitchell D, et al. Among authors: pearsall rs. Mol Cancer Ther. 2010 Feb;9(2):379-88. doi: 10.1158/1535-7163.MCT-09-0650. Epub 2010 Feb 2. Mol Cancer Ther. 2010. PMID: 20124460
A soluble bone morphogenetic protein type IA receptor increases bone mass and bone strength.
Baud'huin M, Solban N, Cornwall-Brady M, Sako D, Kawamoto Y, Liharska K, Lath D, Bouxsein ML, Underwood KW, Ucran J, Kumar R, Pobre E, Grinberg A, Seehra J, Canalis E, Pearsall RS, Croucher PI. Baud'huin M, et al. Among authors: pearsall rs. Proc Natl Acad Sci U S A. 2012 Jul 24;109(30):12207-12. doi: 10.1073/pnas.1204929109. Epub 2012 Jul 3. Proc Natl Acad Sci U S A. 2012. PMID: 22761317 Free PMC article.
Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growth.
Castonguay R, Werner ED, Matthews RG, Presman E, Mulivor AW, Solban N, Sako D, Pearsall RS, Underwood KW, Seehra J, Kumar R, Grinberg AV. Castonguay R, et al. Among authors: pearsall rs. J Biol Chem. 2011 Aug 26;286(34):30034-46. doi: 10.1074/jbc.M111.260133. Epub 2011 Jul 7. J Biol Chem. 2011. PMID: 21737454 Free PMC article.
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