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Plasmodium falciparum neutral aminopeptidases: new targets for anti-malarials.
Skinner-Adams TS, Stack CM, Trenholme KR, Brown CL, Grembecka J, Lowther J, Mucha A, Drag M, Kafarski P, McGowan S, Whisstock JC, Gardiner DL, Dalton JP. Skinner-Adams TS, et al. Among authors: whisstock jc. Trends Biochem Sci. 2010 Jan;35(1):53-61. doi: 10.1016/j.tibs.2009.08.004. Epub 2009 Sep 30. Trends Biochem Sci. 2010. PMID: 19796954 Review.
Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidase.
McGowan S, Porter CJ, Lowther J, Stack CM, Golding SJ, Skinner-Adams TS, Trenholme KR, Teuscher F, Donnelly SM, Grembecka J, Mucha A, Kafarski P, Degori R, Buckle AM, Gardiner DL, Whisstock JC, Dalton JP. McGowan S, et al. Among authors: whisstock jc. Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2537-42. doi: 10.1073/pnas.0807398106. Epub 2009 Feb 5. Proc Natl Acad Sci U S A. 2009. PMID: 19196988 Free PMC article.
Structure of the Plasmodium falciparum M17 aminopeptidase and significance for the design of drugs targeting the neutral exopeptidases.
McGowan S, Oellig CA, Birru WA, Caradoc-Davies TT, Stack CM, Lowther J, Skinner-Adams T, Mucha A, Kafarski P, Grembecka J, Trenholme KR, Buckle AM, Gardiner DL, Dalton JP, Whisstock JC. McGowan S, et al. Among authors: whisstock jc. Proc Natl Acad Sci U S A. 2010 Feb 9;107(6):2449-54. doi: 10.1073/pnas.0911813107. Epub 2010 Jan 21. Proc Natl Acad Sci U S A. 2010. PMID: 20133789 Free PMC article.
Structural mechanisms of inactivation in scabies mite serine protease paralogues.
Fischer K, Langendorf CG, Irving JA, Reynolds S, Willis C, Beckham S, Law RH, Yang S, Bashtannyk-Puhalovich TA, McGowan S, Whisstock JC, Pike RN, Kemp DJ, Buckle AM. Fischer K, et al. Among authors: whisstock jc. J Mol Biol. 2009 Jul 24;390(4):635-45. doi: 10.1016/j.jmb.2009.04.082. Epub 2009 May 7. J Mol Biol. 2009. PMID: 19427318
X-ray crystal structure of MENT: evidence for functional loop-sheet polymers in chromatin condensation.
McGowan S, Buckle AM, Irving JA, Ong PC, Bashtannyk-Puhalovich TA, Kan WT, Henderson KN, Bulynko YA, Popova EY, Smith AI, Bottomley SP, Rossjohn J, Grigoryev SA, Pike RN, Whisstock JC. McGowan S, et al. Among authors: whisstock jc. EMBO J. 2006 Jul 12;25(13):3144-55. doi: 10.1038/sj.emboj.7601201. Epub 2006 Jun 29. EMBO J. 2006. PMID: 16810322 Free PMC article.
DNA accelerates the inhibition of human cathepsin V by serpins.
Ong PC, McGowan S, Pearce MC, Irving JA, Kan WT, Grigoryev SA, Turk B, Silverman GA, Brix K, Bottomley SP, Whisstock JC, Pike RN. Ong PC, et al. Among authors: whisstock jc. J Biol Chem. 2007 Dec 21;282(51):36980-6. doi: 10.1074/jbc.M706991200. Epub 2007 Oct 8. J Biol Chem. 2007. PMID: 17923478 Free article.
270 results