Alterio V - Search Results

1

Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX.

Alterio V, Hilvo M, Di Fiore A, Supuran CT, Pan P, Parkkila S, Scaloni A, Pastorek J, Pastorekova S, Pedone C, Scozzafava A, Monti SM, De Simone G. Alterio V, et al. Proc Natl Acad Sci U S A. 2009 Sep 22;106(38):16233-8. doi: 10.1073/pnas.0908301106. Epub 2009 Sep 14. Proc Natl Acad Sci U S A. 2009. PMID: 19805286 Free PMC article.

2

The crystal structure of an EST2 mutant unveils structural insights on the H group of the carboxylesterase/lipase family.

De Simone G, Menchise V, Alterio V, Mandrich L, Rossi M, Manco G, Pedone C. De Simone G, et al. Among authors: alterio v. J Mol Biol. 2004 Oct 8;343(1):137-46. doi: 10.1016/j.jmb.2004.08.014. J Mol Biol. 2004. PMID: 15381425

3

Carbonic anhydrase inhibitors: stacking with Phe131 determines active site binding region of inhibitors as exemplified by the X-ray crystal structure of a membrane-impermeant antitumor sulfonamide complexed with isozyme II.

Menchise V, De Simone G, Alterio V, Di Fiore A, Pedone C, Scozzafava A, Supuran CT. Menchise V, et al. Among authors: alterio v. J Med Chem. 2005 Sep 8;48(18):5721-7. doi: 10.1021/jm050333c. J Med Chem. 2005. PMID: 16134940

4

Metal ion substitution in the catalytic site greatly affects the binding of sulfhydryl-containing compounds to leucyl aminopeptidase.

Cappiello M, Alterio V, Amodeo P, Del Corso A, Scaloni A, Pedone C, Moschini R, De Donatis GM, De Simone G, Mura U. Cappiello M, et al. Among authors: alterio v. Biochemistry. 2006 Mar 14;45(10):3226-34. doi: 10.1021/bi052069v. Biochemistry. 2006. PMID: 16519517

5

Carbonic anhydrase inhibitors: X-ray and molecular modeling study for the interaction of a fluorescent antitumor sulfonamide with isozyme II and IX.

Alterio V, Vitale RM, Monti SM, Pedone C, Scozzafava A, Cecchi A, De Simone G, Supuran CT. Alterio V, et al. J Am Chem Soc. 2006 Jun 28;128(25):8329-35. doi: 10.1021/ja061574s. J Am Chem Soc. 2006. PMID: 16787097

6

Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.

Alterio V, De Simone G, Monti SM, Scozzafava A, Supuran CT. Alterio V, et al. Bioorg Med Chem Lett. 2007 Aug 1;17(15):4201-7. doi: 10.1016/j.bmcl.2007.05.045. Epub 2007 May 18. Bioorg Med Chem Lett. 2007. PMID: 17540563

7

Functional and structural features of the oxyanion hole in a thermophilic esterase from Alicyclobacillus acidocaldarius.

Mandrich L, Menchise V, Alterio V, De Simone G, Pedone C, Rossi M, Manco G. Mandrich L, et al. Among authors: alterio v. Proteins. 2008 Jun;71(4):1721-31. doi: 10.1002/prot.21877. Proteins. 2008. PMID: 18076040

8

Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-binding, more isoform-selective inhibitors.

Vitale RM, Alterio V, Innocenti A, Winum JY, Monti SM, De Simone G, Supuran CT. Vitale RM, et al. Among authors: alterio v. J Med Chem. 2009 Oct 8;52(19):5990-8. doi: 10.1021/jm900641r. J Med Chem. 2009. PMID: 19731956

9

Crystal structure of an S-formylglutathione hydrolase from Pseudoalteromonas haloplanktis TAC125.

Alterio V, Aurilia V, Romanelli A, Parracino A, Saviano M, D'Auria S, De Simone G. Alterio V, et al. Biopolymers. 2010 Aug;93(8):669-77. doi: 10.1002/bip.21420. Biopolymers. 2010. PMID: 20209484

10

The first example of a significant active site conformational rearrangement in a carbonic anhydrase-inhibitor adduct: the carbonic anhydrase I-topiramate complex.

Alterio V, Monti SM, Truppo E, Pedone C, Supuran CT, De Simone G. Alterio V, et al. Org Biomol Chem. 2010 Aug 7;8(15):3528-33. doi: 10.1039/b926832d. Epub 2010 May 27. Org Biomol Chem. 2010. PMID: 20505865

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