Pei XY - Search Results

1

Bim upregulation by histone deacetylase inhibitors mediates interactions with the Bcl-2 antagonist ABT-737: evidence for distinct roles for Bcl-2, Bcl-xL, and Mcl-1.

Chen S, Dai Y, Pei XY, Grant S. Chen S, et al. Among authors: pei xy. Mol Cell Biol. 2009 Dec;29(23):6149-69. doi: 10.1128/MCB.01481-08. Epub 2009 Oct 5. Mol Cell Biol. 2009. PMID: 19805519 Free PMC article.

2

Synergistic induction of oxidative injury and apoptosis in human multiple myeloma cells by the proteasome inhibitor bortezomib and histone deacetylase inhibitors.

Pei XY, Dai Y, Grant S. Pei XY, et al. Clin Cancer Res. 2004 Jun 1;10(11):3839-52. doi: 10.1158/1078-0432.CCR-03-0561. Clin Cancer Res. 2004. PMID: 15173093

3

The small-molecule Bcl-2 inhibitor HA14-1 interacts synergistically with flavopiridol to induce mitochondrial injury and apoptosis in human myeloma cells through a free radical-dependent and Jun NH2-terminal kinase-dependent mechanism.

Pei XY, Dai Y, Grant S. Pei XY, et al. Mol Cancer Ther. 2004 Dec;3(12):1513-24. Mol Cancer Ther. 2004. PMID: 15634644

4

Dissecting the roles of checkpoint kinase 1/CDC2 and mitogen-activated protein kinase kinase 1/2/extracellular signal-regulated kinase 1/2 in relation to 7-hydroxystaurosporine-induced apoptosis in human multiple myeloma cells.

Pei XY, Li W, Dai Y, Dent P, Grant S. Pei XY, et al. Mol Pharmacol. 2006 Dec;70(6):1965-73. doi: 10.1124/mol.106.028373. Epub 2006 Aug 29. Mol Pharmacol. 2006. PMID: 16940414

5

Statins synergistically potentiate 7-hydroxystaurosporine (UCN-01) lethality in human leukemia and myeloma cells by disrupting Ras farnesylation and activation.

Dai Y, Khanna P, Chen S, Pei XY, Dent P, Grant S. Dai Y, et al. Among authors: pei xy. Blood. 2007 May 15;109(10):4415-23. doi: 10.1182/blood-2006-09-047076. Epub 2007 Jan 30. Blood. 2007. PMID: 17264303 Free PMC article.

6

MEK1/2 inhibitors potentiate UCN-01 lethality in human multiple myeloma cells through a Bim-dependent mechanism.

Pei XY, Dai Y, Tenorio S, Lu J, Harada H, Dent P, Grant S. Pei XY, et al. Blood. 2007 Sep 15;110(6):2092-101. doi: 10.1182/blood-2007-04-083204. Epub 2007 May 31. Blood. 2007. PMID: 17540843 Free PMC article.

7

Vorinostat synergistically potentiates MK-0457 lethality in chronic myelogenous leukemia cells sensitive and resistant to imatinib mesylate.

Dai Y, Chen S, Venditti CA, Pei XY, Nguyen TK, Dent P, Grant S. Dai Y, et al. Among authors: pei xy. Blood. 2008 Aug 1;112(3):793-804. doi: 10.1182/blood-2007-10-116376. Epub 2008 May 27. Blood. 2008. PMID: 18505786 Free PMC article.

8

The NF (Nuclear factor)-κB inhibitor parthenolide interacts with histone deacetylase inhibitors to induce MKK7/JNK1-dependent apoptosis in human acute myeloid leukaemia cells.

Dai Y, Guzman ML, Chen S, Wang L, Yeung SK, Pei XY, Dent P, Jordan CT, Grant S. Dai Y, et al. Among authors: pei xy. Br J Haematol. 2010 Oct;151(1):70-83. doi: 10.1111/j.1365-2141.2010.08319.x. Epub 2010 Aug 2. Br J Haematol. 2010. PMID: 20701602 Free PMC article.

9

Disruption of Src function potentiates Chk1-inhibitor-induced apoptosis in human multiple myeloma cells in vitro and in vivo.

Dai Y, Chen S, Shah R, Pei XY, Wang L, Almenara JA, Kramer LB, Dent P, Grant S. Dai Y, et al. Among authors: pei xy. Blood. 2011 Feb 10;117(6):1947-57. doi: 10.1182/blood-2010-06-291146. Epub 2010 Dec 10. Blood. 2011. PMID: 21148814 Free PMC article.

10

Bortezomib interacts synergistically with belinostat in human acute myeloid leukaemia and acute lymphoblastic leukaemia cells in association with perturbations in NF-κB and Bim.

Dai Y, Chen S, Wang L, Pei XY, Kramer LB, Dent P, Grant S. Dai Y, et al. Among authors: pei xy. Br J Haematol. 2011 Apr;153(2):222-35. doi: 10.1111/j.1365-2141.2011.08591.x. Epub 2011 Mar 6. Br J Haematol. 2011. PMID: 21375523 Free PMC article. Clinical Trial.

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