Jacobson E - Search Results

1

Phase II, randomized, controlled, double-blinded trial of weekly elesclomol plus paclitaxel versus paclitaxel alone for stage IV metastatic melanoma.

O'Day S, Gonzalez R, Lawson D, Weber R, Hutchins L, Anderson C, Haddad J, Kong S, Williams A, Jacobson E. O'Day S, et al. Among authors: jacobson e. J Clin Oncol. 2009 Nov 10;27(32):5452-8. doi: 10.1200/JCO.2008.17.1579. Epub 2009 Oct 13. J Clin Oncol. 2009. PMID: 19826135 Clinical Trial.

2

Phase I trial of intravenous thymidine and carboplatin in patients with advanced cancer.

Robins HI, Tutsch K, Katschinski DM, Jacobson E, Mehta M, Olsen M, Cohen JD, Tiggelaar CL, Arzoomanian RZ, Alberti D, Feierabend C, Wilding G. Robins HI, et al. Among authors: jacobson e. J Clin Oncol. 1999 Sep;17(9):2922-31. doi: 10.1200/JCO.1999.17.9.2922. J Clin Oncol. 1999. PMID: 10561372 Clinical Trial.

3

A phase II, randomized, placebo-controlled, double-blind, multi-dose study of SRT2104, a SIRT1 activator, in subjects with type 2 diabetes.

Baksi A, Kraydashenko O, Zalevkaya A, Stets R, Elliott P, Haddad J, Hoffmann E, Vlasuk GP, Jacobson EW. Baksi A, et al. Among authors: jacobson ew. Br J Clin Pharmacol. 2014 Jul;78(1):69-77. doi: 10.1111/bcp.12327. Br J Clin Pharmacol. 2014. PMID: 24446723 Free PMC article. Clinical Trial.

4

A pilot randomized, placebo controlled, double blind phase I trial of the novel SIRT1 activator SRT2104 in elderly volunteers.

Libri V, Brown AP, Gambarota G, Haddad J, Shields GS, Dawes H, Pinato DJ, Hoffman E, Elliot PJ, Vlasuk GP, Jacobson E, Wilkins MR, Matthews PM. Libri V, et al. Among authors: jacobson e. PLoS One. 2012;7(12):e51395. doi: 10.1371/journal.pone.0051395. Epub 2012 Dec 20. PLoS One. 2012. PMID: 23284689 Free PMC article. Clinical Trial.

5

A Randomized, Placebo-Controlled Study of SRT2104, a SIRT1 Activator, in Patients with Moderate to Severe Psoriasis.

Krueger JG, Suárez-Fariñas M, Cueto I, Khacherian A, Matheson R, Parish LC, Leonardi C, Shortino D, Gupta A, Haddad J, Vlasuk GP, Jacobson EW. Krueger JG, et al. PLoS One. 2015 Nov 10;10(11):e0142081. doi: 10.1371/journal.pone.0142081. eCollection 2015. PLoS One. 2015. PMID: 26556603 Free PMC article. Clinical Trial.

6

Assessing Colonic Exposure, Safety, and Clinical Activity of SRT2104, a Novel Oral SIRT1 Activator, in Patients with Mild to Moderate Ulcerative Colitis.

Sands BE, Joshi S, Haddad J, Freudenberg JM, Oommen DE, Hoffmann E, McCallum SW, Jacobson E. Sands BE, et al. Among authors: jacobson e. Inflamm Bowel Dis. 2016 Mar;22(3):607-14. doi: 10.1097/MIB.0000000000000597. Inflamm Bowel Dis. 2016. PMID: 26595549 Free PMC article. Clinical Trial.

7

Three double-blind, randomized trials evaluating the safety and tolerance of different formulations of the saponin adjuvant QS-21.

Waite DC, Jacobson EW, Ennis FA, Edelman R, White B, Kammer R, Anderson C, Kensil CR. Waite DC, et al. Among authors: jacobson ew. Vaccine. 2001 Jul 16;19(28-29):3957-67. doi: 10.1016/s0264-410x(01)00142-6. Vaccine. 2001. PMID: 11427271 Clinical Trial.

8

Randomized, double-blind, placebo-controlled trial of the oral interleukin-12/23 inhibitor apilimod mesylate for treatment of active Crohn's disease.

Sands BE, Jacobson EW, Sylwestrowicz T, Younes Z, Dryden G, Fedorak R, Greenbloom S. Sands BE, et al. Among authors: jacobson ew. Inflamm Bowel Dis. 2010 Jul;16(7):1209-18. doi: 10.1002/ibd.21159. Inflamm Bowel Dis. 2010. PMID: 19918967 Clinical Trial.

9

Brief report: a phase IIa, randomized, double-blind, placebo-controlled trial of apilimod mesylate, an interleukin-12/interleukin-23 inhibitor, in patients with rheumatoid arthritis.

Krausz S, Boumans MJ, Gerlag DM, Lufkin J, van Kuijk AW, Bakker A, de Boer M, Lodde BM, Reedquist KA, Jacobson EW, O'Meara M, Tak PP. Krausz S, et al. Arthritis Rheum. 2012 Jun;64(6):1750-5. doi: 10.1002/art.34339. Epub 2011 Dec 14. Arthritis Rheum. 2012. PMID: 22170479 Free article. Clinical Trial.

10

Pharmacokinetics and tolerability of SRT2104, a first-in-class small molecule activator of SIRT1, after single and repeated oral administration in man.

Hoffmann E, Wald J, Lavu S, Roberts J, Beaumont C, Haddad J, Elliott P, Westphal C, Jacobson E. Hoffmann E, et al. Among authors: jacobson e. Br J Clin Pharmacol. 2013 Jan;75(1):186-96. doi: 10.1111/j.1365-2125.2012.04340.x. Br J Clin Pharmacol. 2013. PMID: 22616762 Free PMC article. Clinical Trial.

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