Gilbert IH - Search Results

1

Chemical validation of trypanothione synthetase: a potential drug target for human trypanosomiasis.

Torrie LS, Wyllie S, Spinks D, Oza SL, Thompson S, Harrison JR, Gilbert IH, Wyatt PG, Fairlamb AH, Frearson JA. Torrie LS, et al. Among authors: gilbert ih. J Biol Chem. 2009 Dec 25;284(52):36137-36145. doi: 10.1074/jbc.M109.045336. Epub 2009 Oct 14. J Biol Chem. 2009. PMID: 19828449 Free PMC article.

2

An approach to use an unusual adenosine transporter to selectively deliver polyamine analogues to trypanosomes.

Tye CK, Kasinathan G, Barrett MP, Brun R, Doyle VE, Fairlamb AH, Weaver R, Gilbert IH. Tye CK, et al. Among authors: gilbert ih. Bioorg Med Chem Lett. 1998 Apr 7;8(7):811-6. doi: 10.1016/s0960-894x(98)00095-x. Bioorg Med Chem Lett. 1998. PMID: 9871546

3

Synthesis and biological evaluation of phosphate prodrugs of 4-phospho-D-erythronohydroxamic acid, an inhibitor of 6-phosphogluconate dehydrogenase.

Ruda GF, Alibu VP, Mitsos C, Bidet O, Kaiser M, Brun R, Barrett MP, Gilbert IH. Ruda GF, et al. Among authors: gilbert ih. ChemMedChem. 2007 Aug;2(8):1169-80. doi: 10.1002/cmdc.200700040. ChemMedChem. 2007. PMID: 17615587 Free PMC article.

4

Target assessment for antiparasitic drug discovery.

Frearson JA, Wyatt PG, Gilbert IH, Fairlamb AH. Frearson JA, et al. Among authors: gilbert ih. Trends Parasitol. 2007 Dec;23(12):589-95. doi: 10.1016/j.pt.2007.08.019. Epub 2007 Oct 24. Trends Parasitol. 2007. PMID: 17962072 Free PMC article. Review.

5

Lessons learnt from assembling screening libraries for drug discovery for neglected diseases.

Brenk R, Schipani A, James D, Krasowski A, Gilbert IH, Frearson J, Wyatt PG. Brenk R, et al. Among authors: gilbert ih. ChemMedChem. 2008 Mar;3(3):435-44. doi: 10.1002/cmdc.200700139. ChemMedChem. 2008. PMID: 18064617 Free PMC article.

6

Targeted delivery of compounds to Trypanosoma brucei using the melamine motif.

Chollet C, Baliani A, Wong PE, Barrett MP, Gilbert IH. Chollet C, et al. Among authors: gilbert ih. Bioorg Med Chem. 2009 Mar 15;17(6):2512-23. doi: 10.1016/j.bmc.2009.01.058. Epub 2009 Jan 31. Bioorg Med Chem. 2009. PMID: 19250832

7

Novel functionalized melamine-based nitroheterocycles: synthesis and activity against trypanosomatid parasites.

Baliani A, Peal V, Gros L, Brun R, Kaiser M, Barrett MP, Gilbert IH. Baliani A, et al. Among authors: gilbert ih. Org Biomol Chem. 2009 Mar 21;7(6):1154-66. doi: 10.1039/b813394h. Epub 2009 Jan 28. Org Biomol Chem. 2009. PMID: 19262935

8

One scaffold, three binding modes: novel and selective pteridine reductase 1 inhibitors derived from fragment hits discovered by virtual screening.

Mpamhanga CP, Spinks D, Tulloch LB, Shanks EJ, Robinson DA, Collie IT, Fairlamb AH, Wyatt PG, Frearson JA, Hunter WN, Gilbert IH, Brenk R. Mpamhanga CP, et al. Among authors: gilbert ih. J Med Chem. 2009 Jul 23;52(14):4454-65. doi: 10.1021/jm900414x. J Med Chem. 2009. PMID: 19527033 Free PMC article.

9

Improved tricyclic inhibitors of trypanothione reductase by screening and chemical synthesis.

Richardson JL, Nett IR, Jones DC, Abdille MH, Gilbert IH, Fairlamb AH. Richardson JL, et al. Among authors: gilbert ih. ChemMedChem. 2009 Aug;4(8):1333-40. doi: 10.1002/cmdc.200900097. ChemMedChem. 2009. PMID: 19557801 Free PMC article.

10

Synthesis and evaluation of 1-(1-(Benzo[b]thiophen-2-yl)cyclohexyl)piperidine (BTCP) analogues as inhibitors of trypanothione reductase.

Patterson S, Jones DC, Shanks EJ, Frearson JA, Gilbert IH, Wyatt PG, Fairlamb AH. Patterson S, et al. Among authors: gilbert ih. ChemMedChem. 2009 Aug;4(8):1341-53. doi: 10.1002/cmdc.200900098. ChemMedChem. 2009. PMID: 19557802 Free PMC article.

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