Trotta R - Search Results

1

Tandem application of virtual screening and NMR experiments in the discovery of brand new DNA quadruplex groove binders.

Cosconati S, Marinelli L, Trotta R, Virno A, Mayol L, Novellino E, Olson AJ, Randazzo A. Cosconati S, et al. Among authors: trotta r. J Am Chem Soc. 2009 Nov 18;131(45):16336-7. doi: 10.1021/ja9063662. J Am Chem Soc. 2009. PMID: 19856964

2

Structural and conformational requisites in DNA quadruplex groove binding: another piece to the puzzle.

Cosconati S, Marinelli L, Trotta R, Virno A, De Tito S, Romagnoli R, Pagano B, Limongelli V, Giancola C, Baraldi PG, Mayol L, Novellino E, Randazzo A. Cosconati S, et al. Among authors: trotta r. J Am Chem Soc. 2010 May 12;132(18):6425-33. doi: 10.1021/ja1003872. J Am Chem Soc. 2010. PMID: 20394365

3

A more detailed picture of the interactions between virtual screening-derived hits and the DNA G-quadruplex: NMR, molecular modelling and ITC studies.

Trotta R, De Tito S, Lauri I, La Pietra V, Marinelli L, Cosconati S, Martino L, Conte MR, Mayol L, Novellino E, Randazzo A. Trotta R, et al. Biochimie. 2011 Aug;93(8):1280-7. doi: 10.1016/j.biochi.2011.05.021. Epub 2011 May 30. Biochimie. 2011. PMID: 21658428

4

State-of-the-art methodologies for the discovery and characterization of DNA G-quadruplex binders.

Pagano B, Cosconati S, Gabelica V, Petraccone L, De Tito S, Marinelli L, La Pietra V, di Leva FS, Lauri I, Trotta R, Novellino E, Giancola C, Randazzo A. Pagano B, et al. Among authors: trotta r. Curr Pharm Des. 2012;18(14):1880-99. doi: 10.2174/138161212799958332. Curr Pharm Des. 2012. PMID: 22376104 Free article. Review.

5

Shooting for selective druglike G-quadruplex binders: evidence for telomeric DNA damage and tumor cell death.

Cosconati S, Rizzo A, Trotta R, Pagano B, Iachettini S, De Tito S, Lauri I, Fotticchia I, Giustiniano M, Marinelli L, Giancola C, Novellino E, Biroccio A, Randazzo A. Cosconati S, et al. Among authors: trotta r. J Med Chem. 2012 Nov 26;55(22):9785-92. doi: 10.1021/jm301019w. Epub 2012 Oct 18. J Med Chem. 2012. PMID: 23057850

6

The G-triplex DNA.

Limongelli V, De Tito S, Cerofolini L, Fragai M, Pagano B, Trotta R, Cosconati S, Marinelli L, Novellino E, Bertini I, Randazzo A, Luchinat C, Parrinello M. Limongelli V, et al. Among authors: trotta r. Angew Chem Int Ed Engl. 2013 Feb 18;52(8):2269-73. doi: 10.1002/anie.201206522. Epub 2013 Jan 17. Angew Chem Int Ed Engl. 2013. PMID: 23335456 No abstract available.

7

A non-empirical chromophoric interpretation of CD spectra of DNA G-quadruplex structures.

Masiero S, Trotta R, Pieraccini S, De Tito S, Perone R, Randazzo A, Spada GP. Masiero S, et al. Among authors: trotta r. Org Biomol Chem. 2010 Jun 21;8(12):2683-92. doi: 10.1039/c003428b. Epub 2010 May 4. Org Biomol Chem. 2010. PMID: 20440429

8

Resonance assignment of human LARP4A La module.

Cruz-Gallardo I, Martino L, Trotta R, De Tito S, Kelly G, Atkinson RA, Randazzo A, Conte MR. Cruz-Gallardo I, et al. Among authors: trotta r. Biomol NMR Assign. 2019 Apr;13(1):169-172. doi: 10.1007/s12104-019-09871-4. Epub 2019 Jan 10. Biomol NMR Assign. 2019. PMID: 30632004 Free PMC article.

9

NMR spectrometers as "magnetic tongues": prediction of sensory descriptors in canned tomatoes.

Malmendal A, Amoresano C, Trotta R, Lauri I, De Tito S, Novellino E, Randazzo A. Malmendal A, et al. Among authors: trotta r. J Agric Food Chem. 2011 Oct 26;59(20):10831-8. doi: 10.1021/jf203803q. Epub 2011 Oct 5. J Agric Food Chem. 2011. PMID: 21942325

10

LARP4A recognizes polyA RNA via a novel binding mechanism mediated by disordered regions and involving the PAM2w motif, revealing interplay between PABP, LARP4A and mRNA.

Cruz-Gallardo I, Martino L, Kelly G, Atkinson RA, Trotta R, De Tito S, Coleman P, Ahdash Z, Gu Y, Bui TTT, Conte MR. Cruz-Gallardo I, et al. Among authors: trotta r. Nucleic Acids Res. 2019 May 7;47(8):4272-4291. doi: 10.1093/nar/gkz144. Nucleic Acids Res. 2019. PMID: 30820564 Free PMC article.

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