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Molecular recognition at the active site of catechol-o-methyltransferase: energetically favorable replacement of a water molecule imported by a bisubstrate inhibitor.
Ellermann M, Jakob-Roetne R, Lerner C, Borroni E, Schlatter D, Roth D, Ehler A, Rudolph MG, Diederich F. Ellermann M, et al. Among authors: borroni e. Angew Chem Int Ed Engl. 2009;48(48):9092-6. doi: 10.1002/anie.200904410. Angew Chem Int Ed Engl. 2009. PMID: 19882607 No abstract available.
X-ray Crystal Structure of a Bisubstrate Inhibitor Bound to the Enzyme Catechol-O-methyltransferase: A Dramatic Effect of Inhibitor Preorganization on Binding Affinity We thank F. Hoffmann-La Roche for generous support of this work. We are grateful to P. Malherbe for the cloning of COMT, P. Caspers for the expression of COMT, A. Cesura for enzyme purification, B. Wipf for fermentation, and H. W. Lahm for sequencing.
Lerner C, Ruf A, Gramlich V, Masjost B, Zürcher G, Jakob-Roetne R, Borroni E, Diederich F. Lerner C, et al. Among authors: borroni e. Angew Chem Int Ed Engl. 2001 Nov 5;40(21):4040-4042. Angew Chem Int Ed Engl. 2001. PMID: 12404486 No abstract available.
X-ray Crystal Structure of a Bisubstrate Inhibitor Bound to the Enzyme Catechol-O-methyltransferase: A Dramatic Effect of Inhibitor Preorganization on Binding Affinity.
Lerner C, Ruf A, Gramlich V, Masjost B, Zürcher G, Jakob-Roetne R, Borroni E, Diederich F. Lerner C, et al. Among authors: borroni e. Angew Chem Int Ed Engl. 2001 Nov 5;40(21):4040-4042. doi: 10.1002/1521-3773(20011105)40:21<4040::AID-ANIE4040>3.0.CO;2-C. Angew Chem Int Ed Engl. 2001. PMID: 29712241
Mosé Da Prada and the discovery of tolcapone.
Borroni E, Borgulya J, Zürcher G. Borroni E, et al. J Neural Transm Suppl. 1998;52:XIII-XVI. J Neural Transm Suppl. 1998. PMID: 9564601 No abstract available.
244 results