Wang J - Search Results

1

Design and pharmacological characterization of inhibitors of amantadine-resistant mutants of the M2 ion channel of influenza A virus.

Balannik V, Wang J, Ohigashi Y, Jing X, Magavern E, Lamb RA, Degrado WF, Pinto LH. Balannik V, et al. Among authors: wang j. Biochemistry. 2009 Dec 22;48(50):11872-82. doi: 10.1021/bi9014488. Biochemistry. 2009. PMID: 19905033 Free PMC article.

2

Discovery of spiro-piperidine inhibitors and their modulation of the dynamics of the M2 proton channel from influenza A virus.

Wang J, Cady SD, Balannik V, Pinto LH, DeGrado WF, Hong M. Wang J, et al. J Am Chem Soc. 2009 Jun 17;131(23):8066-76. doi: 10.1021/ja900063s. J Am Chem Soc. 2009. PMID: 19469531 Free PMC article.

3

Solid-supported membrane technology for the investigation of the influenza A virus M2 channel activity.

Balannik V, Obrdlik P, Inayat S, Steensen C, Wang J, Rausch JM, DeGrado WF, Kelety B, Pinto LH. Balannik V, et al. Among authors: wang j. Pflugers Arch. 2010 Mar;459(4):593-605. doi: 10.1007/s00424-009-0760-1. Epub 2009 Nov 28. Pflugers Arch. 2010. PMID: 19946785 Free PMC article.

4

Structure of the amantadine binding site of influenza M2 proton channels in lipid bilayers.

Cady SD, Schmidt-Rohr K, Wang J, Soto CS, Degrado WF, Hong M. Cady SD, et al. Among authors: wang j. Nature. 2010 Feb 4;463(7281):689-92. doi: 10.1038/nature08722. Nature. 2010. PMID: 20130653 Free PMC article.

5

Proton and cation transport activity of the M2 proton channel from influenza A virus.

Leiding T, Wang J, Martinsson J, DeGrado WF, Arsköld SP. Leiding T, et al. Among authors: wang j. Proc Natl Acad Sci U S A. 2010 Aug 31;107(35):15409-14. doi: 10.1073/pnas.1009997107. Epub 2010 Aug 16. Proc Natl Acad Sci U S A. 2010. PMID: 20713739 Free PMC article.

6

Structural and dynamic mechanisms for the function and inhibition of the M2 proton channel from influenza A virus.

Wang J, Qiu JX, Soto C, DeGrado WF. Wang J, et al. Curr Opin Struct Biol. 2011 Feb;21(1):68-80. doi: 10.1016/j.sbi.2010.12.002. Epub 2011 Jan 17. Curr Opin Struct Biol. 2011. PMID: 21247754 Free PMC article. Review.

7

Specific binding of adamantane drugs and direction of their polar amines in the pore of the influenza M2 transmembrane domain in lipid bilayers and dodecylphosphocholine micelles determined by NMR spectroscopy.

Cady SD, Wang J, Wu Y, DeGrado WF, Hong M. Cady SD, et al. Among authors: wang j. J Am Chem Soc. 2011 Mar 30;133(12):4274-84. doi: 10.1021/ja102581n. Epub 2011 Mar 7. J Am Chem Soc. 2011. PMID: 21381693 Free PMC article.

8

Photoinduced electron transfer and fluorophore motion as a probe of the conformational dynamics of membrane proteins: application to the influenza a M2 proton channel.

Rogers JM, Polishchuk AL, Guo L, Wang J, DeGrado WF, Gai F. Rogers JM, et al. Among authors: wang j. Langmuir. 2011 Apr 5;27(7):3815-21. doi: 10.1021/la200480d. Epub 2011 Mar 14. Langmuir. 2011. PMID: 21401044 Free PMC article.

9

Exploring the size limit of templates for inhibitors of the M2 ion channel of influenza A virus.

Duque MD, Ma C, Torres E, Wang J, Naesens L, Juárez-Jiménez J, Camps P, Luque FJ, DeGrado WF, Lamb RA, Pinto LH, Vázquez S. Duque MD, et al. Among authors: wang j. J Med Chem. 2011 Apr 28;54(8):2646-57. doi: 10.1021/jm101334y. Epub 2011 Apr 5. J Med Chem. 2011. PMID: 21466220 Free PMC article.

10

Exploring the Requirements for the Hydrophobic Scaffold and Polar Amine in inhibitors of M2 from Influenza A Virus.

Wang J, Ma C, Balannik V, Pinto LH, Lamb RA, Degrado WF. Wang J, et al. ACS Med Chem Lett. 2011 Apr 14;2(4):307-312. doi: 10.1021/ml100297w. ACS Med Chem Lett. 2011. PMID: 21691418 Free PMC article.

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