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[6S]-5-methyltetrahydrofolate increases plasma folate more effectively than folic acid in women with the homozygous or wild-type 677C-->T polymorphism of methylenetetrahydrofolate reductase.
Prinz-Langenohl R, Brämswig S, Tobolski O, Smulders YM, Smith DE, Finglas PM, Pietrzik K. Prinz-Langenohl R, et al. Among authors: smith de. Br J Pharmacol. 2009 Dec;158(8):2014-21. doi: 10.1111/j.1476-5381.2009.00492.x. Br J Pharmacol. 2009. PMID: 19917061 Free PMC article. Clinical Trial.
Dihydrofolate reductase deficiency due to a homozygous DHFR mutation causes megaloblastic anemia and cerebral folate deficiency leading to severe neurologic disease.
Cario H, Smith DE, Blom H, Blau N, Bode H, Holzmann K, Pannicke U, Hopfner KP, Rump EM, Ayric Z, Kohne E, Debatin KM, Smulders Y, Schwarz K. Cario H, et al. Among authors: smith de. Am J Hum Genet. 2011 Feb 11;88(2):226-31. doi: 10.1016/j.ajhg.2011.01.007. Am J Hum Genet. 2011. PMID: 21310277 Free PMC article.
1,353 results