Roth BD - Search Results

1

Inhibitors of cholesterol biosynthesis. 4. trans-6-[2-(substituted-quinolinyl)ethenyl/ethyl]tetrahydro-4-hydroxy-2 H-pyran-2-ones, a novel series of HMG-CoA reductase inhibitors.

Sliskovic DR, Picard JA, Roark WH, Roth BD, Ferguson E, Krause BR, Newton RS, Sekerke C, Shaw MK. Sliskovic DR, et al. Among authors: roth bd. J Med Chem. 1991 Jan;34(1):367-73. doi: 10.1021/jm00105a057. J Med Chem. 1991. PMID: 1992138

2

Inhibitors of acyl-CoA:cholesterol acyltransferase. 1. Identification and structure-activity relationships of a novel series of fatty acid anilide hypocholesterolemic agents.

Roth BD, Blankley CJ, Hoefle ML, Holmes A, Roark WH, Trivedi BK, Essenburg AD, Kieft KA, Krause BR, Stanfield RL. Roth BD, et al. J Med Chem. 1992 May 1;35(9):1609-17. doi: 10.1021/jm00087a016. J Med Chem. 1992. PMID: 1578488

3

Inhibitors of cholesterol biosynthesis. 6. trans-6-[2-(2-N-heteroaryl-3,5-disubstituted- pyrazol-4-yl)ethyl/ethenyl]tetrahydro-4-hydroxy-2H-pyran-2-ones.

Sliskovic DR, Blankley CJ, Krause BR, Newton RS, Picard JA, Roark WH, Roth BD, Sekerke C, Shaw MK, Stanfield RL. Sliskovic DR, et al. Among authors: roth bd. J Med Chem. 1992 May 29;35(11):2095-103. doi: 10.1021/jm00089a022. J Med Chem. 1992. PMID: 1597859

4

Hepatic and nonhepatic sterol synthesis and tissue distribution following administration of a liver selective HMG-CoA reductase inhibitor, CI-981: comparison with selected HMG-CoA reductase inhibitors.

Bocan TM, Ferguson E, McNally W, Uhlendorf PD, Bak Mueller S, Dehart P, Sliskovic DR, Roth BD, Krause BR, Newton RS. Bocan TM, et al. Among authors: roth bd. Biochim Biophys Acta. 1992 Jan 24;1123(2):133-44. doi: 10.1016/0005-2760(92)90103-3. Biochim Biophys Acta. 1992. PMID: 1739744

5

Inhibitors of cholesterol biosynthesis. 3. Tetrahydro-4-hydroxy-6-[2-(1H-pyrrol-1-yl)ethyl]-2H-pyran-2-one inhibitors of HMG-CoA reductase. 2. Effects of introducing substituents at positions three and four of the pyrrole nucleus.

Roth BD, Blankley CJ, Chucholowski AW, Ferguson E, Hoefle ML, Ortwine DF, Newton RS, Sekerke CS, Sliskovic DR, Stratton CD, et al. Roth BD, et al. J Med Chem. 1991 Jan;34(1):357-66. doi: 10.1021/jm00105a056. J Med Chem. 1991. PMID: 1992137

6

Relationship between tissue selectivity and lipophilicity for inhibitors of HMG-CoA reductase.

Roth BD, Bocan TM, Blankley CJ, Chucholowski AW, Creger PL, Creswell MW, Ferguson E, Newton RS, O'Brien P, Picard JA, et al. Roth BD, et al. J Med Chem. 1991 Jan;34(1):463-6. doi: 10.1021/jm00105a071. J Med Chem. 1991. PMID: 1992149 No abstract available.

7

Hep-G2 cells and primary rat hepatocytes differ in their response to inhibitors of HMG-CoA reductase.

Shaw MK, Newton RS, Sliskovic DR, Roth BD, Ferguson E, Krause BR. Shaw MK, et al. Among authors: roth bd. Biochem Biophys Res Commun. 1990 Jul 31;170(2):726-34. doi: 10.1016/0006-291x(90)92151-o. Biochem Biophys Res Commun. 1990. PMID: 2166504

8

Inhibitors of cholesterol biosynthesis. 1. trans-6-(2-pyrrol-1-ylethyl)-4-hydroxypyran-2-ones, a novel series of HMG-CoA reductase inhibitors. 1. Effects of structural modifications at the 2- and 5-positions of the pyrrole nucleus.

Roth BD, Ortwine DF, Hoefle ML, Stratton CD, Sliskovic DR, Wilson MW, Newton RS. Roth BD, et al. J Med Chem. 1990 Jan;33(1):21-31. doi: 10.1021/jm00163a005. J Med Chem. 1990. PMID: 2296019

9

Inhibitors of cholesterol biosynthesis. 2. 1,3,5-trisubstituted [2-(tetrahydro-4-hydroxy-2-oxopyran-6-yl)ethyl]pyrazoles.

Sliskovic DR, Roth BD, Wilson MW, Hoefle ML, Newton RS. Sliskovic DR, et al. Among authors: roth bd. J Med Chem. 1990 Jan;33(1):31-8. doi: 10.1021/jm00163a006. J Med Chem. 1990. PMID: 2296027

10

Inhibitors of acyl-CoA:cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. 8. Incorporation of amide or amine functionalities into a series of disubstituted ureas and carbamates. Effects on ACAT inhibition in vitro and efficacy in vivo.

O'Brien PM, Sliskovic DR, Blankley CJ, Roth BD, Wilson MW, Hamelehle KL, Krause BR, Stanfield RL. O'Brien PM, et al. Among authors: roth bd. J Med Chem. 1994 Jun 10;37(12):1810-22. doi: 10.1021/jm00038a010. J Med Chem. 1994. PMID: 8021920

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