Shanks EJ - Search Results

1

Investigation of trypanothione reductase as a drug target in Trypanosoma brucei.

Spinks D, Shanks EJ, Cleghorn LA, McElroy S, Jones D, James D, Fairlamb AH, Frearson JA, Wyatt PG, Gilbert IH. Spinks D, et al. Among authors: shanks ej. ChemMedChem. 2009 Dec;4(12):2060-9. doi: 10.1002/cmdc.200900262. ChemMedChem. 2009. PMID: 19924760 Free PMC article.

2

One scaffold, three binding modes: novel and selective pteridine reductase 1 inhibitors derived from fragment hits discovered by virtual screening.

Mpamhanga CP, Spinks D, Tulloch LB, Shanks EJ, Robinson DA, Collie IT, Fairlamb AH, Wyatt PG, Frearson JA, Hunter WN, Gilbert IH, Brenk R. Mpamhanga CP, et al. Among authors: shanks ej. J Med Chem. 2009 Jul 23;52(14):4454-65. doi: 10.1021/jm900414x. J Med Chem. 2009. PMID: 19527033 Free PMC article.

3

Synthesis and evaluation of 1-(1-(Benzo[b]thiophen-2-yl)cyclohexyl)piperidine (BTCP) analogues as inhibitors of trypanothione reductase.

Patterson S, Jones DC, Shanks EJ, Frearson JA, Gilbert IH, Wyatt PG, Fairlamb AH. Patterson S, et al. Among authors: shanks ej. ChemMedChem. 2009 Aug;4(8):1341-53. doi: 10.1002/cmdc.200900098. ChemMedChem. 2009. PMID: 19557802 Free PMC article.

4

Development and validation of a cytochrome c-coupled assay for pteridine reductase 1 and dihydrofolate reductase.

Shanks EJ, Ong HB, Robinson DA, Thompson S, Sienkiewicz N, Fairlamb AH, Frearson JA. Shanks EJ, et al. Anal Biochem. 2010 Jan 15;396(2):194-203. doi: 10.1016/j.ab.2009.09.003. Epub 2009 Sep 11. Anal Biochem. 2010. PMID: 19748480 Free PMC article.

5

Design, synthesis and biological evaluation of novel inhibitors of Trypanosoma brucei pteridine reductase 1.

Spinks D, Ong HB, Mpamhanga CP, Shanks EJ, Robinson DA, Collie IT, Read KD, Frearson JA, Wyatt PG, Brenk R, Fairlamb AH, Gilbert IH. Spinks D, et al. Among authors: shanks ej. ChemMedChem. 2011 Feb 7;6(2):302-8. doi: 10.1002/cmdc.201000450. Epub 2010 Dec 29. ChemMedChem. 2011. PMID: 21275054 Free PMC article.

6

Dihydroquinazolines as a novel class of Trypanosoma brucei trypanothione reductase inhibitors: discovery, synthesis, and characterization of their binding mode by protein crystallography.

Patterson S, Alphey MS, Jones DC, Shanks EJ, Street IP, Frearson JA, Wyatt PG, Gilbert IH, Fairlamb AH. Patterson S, et al. Among authors: shanks ej. J Med Chem. 2011 Oct 13;54(19):6514-30. doi: 10.1021/jm200312v. Epub 2011 Sep 1. J Med Chem. 2011. PMID: 21851087 Free PMC article.

7

LIM kinase inhibitors disrupt mitotic microtubule organization and impair tumor cell proliferation.

Mardilovich K, Baugh M, Crighton D, Kowalczyk D, Gabrielsen M, Munro J, Croft DR, Lourenco F, James D, Kalna G, McGarry L, Rath O, Shanks E, Garnett MJ, McDermott U, Brookfield J, Charles M, Hammonds T, Olson MF. Mardilovich K, et al. Oncotarget. 2015 Nov 17;6(36):38469-86. doi: 10.18632/oncotarget.6288. Oncotarget. 2015. PMID: 26540348 Free PMC article.

8

The High-Affinity Interaction between ORC and DNA that Is Required for Replication Licensing Is Inhibited by 2-Arylquinolin-4-Amines.

Gardner NJ, Gillespie PJ, Carrington JT, Shanks EJ, McElroy SP, Haagensen EJ, Frearson JA, Woodland A, Blow JJ. Gardner NJ, et al. Among authors: shanks ej. Cell Chem Biol. 2017 Aug 17;24(8):981-992.e4. doi: 10.1016/j.chembiol.2017.06.019. Epub 2017 Aug 3. Cell Chem Biol. 2017. PMID: 28781123 Free PMC article.

9

Targeting BCR-ABL-Independent TKI Resistance in Chronic Myeloid Leukemia by mTOR and Autophagy Inhibition.

Mitchell R, Hopcroft LEM, Baquero P, Allan EK, Hewit K, James D, Hamilton G, Mukhopadhyay A, O'Prey J, Hair A, Melo JV, Chan E, Ryan KM, Maguer-Satta V, Druker BJ, Clark RE, Mitra S, Herzyk P, Nicolini FE, Salomoni P, Shanks E, Calabretta B, Holyoake TL, Helgason GV. Mitchell R, et al. J Natl Cancer Inst. 2018 May 1;110(5):467-478. doi: 10.1093/jnci/djx236. J Natl Cancer Inst. 2018. PMID: 29165716 Free PMC article.

10

A functional genomics screen reveals a strong synergistic effect between docetaxel and the mitotic gene DLGAP5 that is mediated by the androgen receptor.

Hewit K, Sandilands E, Martinez RS, James D, Leung HY, Bryant DM, Shanks E, Markert EK. Hewit K, et al. Cell Death Dis. 2018 Oct 19;9(11):1069. doi: 10.1038/s41419-018-1115-7. Cell Death Dis. 2018. PMID: 30341281 Free PMC article.

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