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Page 1
Synthesis and evaluation of 3'-azido-2',3'-dideoxypurine nucleosides as inhibitors of human immunodeficiency virus.
Zhang HW, Coats SJ, Bondada L, Amblard F, Detorio M, Asif G, Fromentin E, Solomon S, Obikhod A, Whitaker T, Sluis-Cremer N, Mellors JW, Schinazi RF. Zhang HW, et al. Among authors: detorio m. Bioorg Med Chem Lett. 2010 Jan 1;20(1):60-4. doi: 10.1016/j.bmcl.2009.11.031. Epub 2009 Nov 13. Bioorg Med Chem Lett. 2010. PMID: 19948402 Free PMC article.
Synthesis and antiviral activity of 2'-deoxy-2'-fluoro-2'-C-methyl-7-deazapurine nucleosides, their phosphoramidate prodrugs and 5'-triphosphates.
Shi J, Zhou L, Zhang H, McBrayer TR, Detorio MA, Johns M, Bassit L, Powdrill MH, Whitaker T, Coats SJ, Götte M, Schinazi RF. Shi J, et al. Among authors: detorio ma. Bioorg Med Chem Lett. 2011 Dec 1;21(23):7094-8. doi: 10.1016/j.bmcl.2011.09.089. Epub 2011 Sep 29. Bioorg Med Chem Lett. 2011. PMID: 22014549 Free PMC article.
Anti-human immunodeficiency virus activity, cross-resistance, cytotoxicity, and intracellular pharmacology of the 3'-azido-2',3'-dideoxypurine nucleosides.
Sluis-Cremer N, Koontz D, Bassit L, Hernandez-Santiago BI, Detorio M, Rapp KL, Amblard F, Bondada L, Grier J, Coats SJ, Schinazi RF, Mellors JW. Sluis-Cremer N, et al. Among authors: detorio m. Antimicrob Agents Chemother. 2009 Sep;53(9):3715-9. doi: 10.1128/AAC.00392-09. Epub 2009 Jul 13. Antimicrob Agents Chemother. 2009. PMID: 19596885 Free PMC article.
Synthesis of purine modified 2'-C-methyl nucleosides as potential anti-HCV agents.
Zhang HW, Zhou L, Coats SJ, McBrayer TR, Tharnish PM, Bondada L, Detorio M, Amichai SA, Johns MD, Whitaker T, Schinazi RF. Zhang HW, et al. Among authors: detorio m. Bioorg Med Chem Lett. 2011 Nov 15;21(22):6788-92. doi: 10.1016/j.bmcl.2011.09.034. Epub 2011 Sep 20. Bioorg Med Chem Lett. 2011. PMID: 21983447 Free PMC article.
Molecular docking and antiviral activity of N-substituted benzyl/phenyl-2-(3,4-dimethyl-5,5-dioxidopyrazolo[4,3-c][1,2]benzothiazin-2(4H)-yl)acetamides.
Ahmad M, Aslam S, Rizvi SU, Muddassar M, Ashfaq UA, Montero C, Ollinger O, Detorio M, Gardiner JM, Schinazi RF. Ahmad M, et al. Among authors: detorio m. Bioorg Med Chem Lett. 2015 Mar 15;25(6):1348-51. doi: 10.1016/j.bmcl.2015.01.007. Epub 2015 Jan 22. Bioorg Med Chem Lett. 2015. PMID: 25701249 Free PMC article.
β-D-2'-C-Methyl-2,6-diaminopurine Ribonucleoside Phosphoramidates are Potent and Selective Inhibitors of Hepatitis C Virus (HCV) and Are Bioconverted Intracellularly to Bioactive 2,6-Diaminopurine and Guanosine 5'-Triphosphate Forms.
Zhou L, Zhang HW, Tao S, Bassit L, Whitaker T, McBrayer TR, Ehteshami M, Amiralaei S, Pradere U, Cho JH, Amblard F, Bobeck D, Detorio M, Coats SJ, Schinazi RF. Zhou L, et al. Among authors: detorio m. J Med Chem. 2015 Apr 23;58(8):3445-58. doi: 10.1021/jm501874e. Epub 2015 Apr 7. J Med Chem. 2015. PMID: 25849312 Free PMC article.
61 results