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Disruption of inducible 6-phosphofructo-2-kinase ameliorates diet-induced adiposity but exacerbates systemic insulin resistance and adipose tissue inflammatory response.
Huo Y, Guo X, Li H, Wang H, Zhang W, Wang Y, Zhou H, Gao Z, Telang S, Chesney J, Chen YE, Ye J, Chapkin RS, Wu C. Huo Y, et al. Among authors: wu c. J Biol Chem. 2010 Feb 5;285(6):3713-3721. doi: 10.1074/jbc.M109.058446. Epub 2009 Nov 30. J Biol Chem. 2010. PMID: 19948719 Free PMC article.
Targeted overexpression of inducible 6-phosphofructo-2-kinase in adipose tissue increases fat deposition but protects against diet-induced insulin resistance and inflammatory responses.
Huo Y, Guo X, Li H, Xu H, Halim V, Zhang W, Wang H, Fan YY, Ong KT, Woo SL, Chapkin RS, Mashek DG, Chen Y, Dong H, Lu F, Wei L, Wu C. Huo Y, et al. Among authors: wu c. J Biol Chem. 2012 Jun 15;287(25):21492-500. doi: 10.1074/jbc.M112.370379. Epub 2012 May 3. J Biol Chem. 2012. PMID: 22556414 Free PMC article.
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