Ellman JA - Search Results

1

Aminopeptidase fingerprints, an integrated approach for identification of good substrates and optimal inhibitors.

Drag M, Bogyo M, Ellman JA, Salvesen GS. Drag M, et al. Among authors: ellman ja. J Biol Chem. 2010 Jan 29;285(5):3310-8. doi: 10.1074/jbc.M109.060418. Epub 2009 Nov 30. J Biol Chem. 2010. PMID: 19948737 Free PMC article.

2

Substrate profiling of cysteine proteases using a combinatorial peptide library identifies functionally unique specificities.

Choe Y, Leonetti F, Greenbaum DC, Lecaille F, Bogyo M, Brömme D, Ellman JA, Craik CS. Choe Y, et al. Among authors: ellman ja. J Biol Chem. 2006 May 5;281(18):12824-32. doi: 10.1074/jbc.M513331200. Epub 2006 Mar 6. J Biol Chem. 2006. PMID: 16520377 Free article.

3

Identification and evaluation of small molecule pan-caspase inhibitors in Huntington's disease models.

Leyva MJ, Degiacomo F, Kaltenbach LS, Holcomb J, Zhang N, Gafni J, Park H, Lo DC, Salvesen GS, Ellerby LM, Ellman JA. Leyva MJ, et al. Among authors: ellman ja. Chem Biol. 2010 Nov 24;17(11):1189-200. doi: 10.1016/j.chembiol.2010.08.014. Chem Biol. 2010. PMID: 21095569 Free PMC article.

4

Positional-scanning fluorigenic substrate libraries reveal unexpected specificity determinants of DUBs (deubiquitinating enzymes).

Drag M, Mikolajczyk J, Bekes M, Reyes-Turcu FE, Ellman JA, Wilkinson KD, Salvesen GS. Drag M, et al. Among authors: ellman ja. Biochem J. 2008 Nov 1;415(3):367-75. doi: 10.1042/BJ20080779. Biochem J. 2008. PMID: 18601651 Free PMC article.

5

Functional studies of Plasmodium falciparum dipeptidyl aminopeptidase I using small molecule inhibitors and active site probes.

Deu E, Leyva MJ, Albrow VE, Rice MJ, Ellman JA, Bogyo M. Deu E, et al. Among authors: ellman ja. Chem Biol. 2010 Aug 27;17(8):808-19. doi: 10.1016/j.chembiol.2010.06.007. Chem Biol. 2010. PMID: 20797610 Free PMC article.

6

A nonpeptidic cathepsin S activity-based probe for noninvasive optical imaging of tumor-associated macrophages.

Verdoes M, Edgington LE, Scheeren FA, Leyva M, Blum G, Weiskopf K, Bachmann MH, Ellman JA, Bogyo M. Verdoes M, et al. Among authors: ellman ja. Chem Biol. 2012 May 25;19(5):619-28. doi: 10.1016/j.chembiol.2012.03.012. Chem Biol. 2012. PMID: 22633413 Free PMC article.

7

Design of a highly selective quenched activity-based probe and its application in dual color imaging studies of cathepsin S activity localization.

Oresic Bender K, Ofori L, van der Linden WA, Mock ED, Datta GK, Chowdhury S, Li H, Segal E, Sanchez Lopez M, Ellman JA, Figdor CG, Bogyo M, Verdoes M. Oresic Bender K, et al. Among authors: ellman ja. J Am Chem Soc. 2015 Apr 15;137(14):4771-7. doi: 10.1021/jacs.5b00315. Epub 2015 Apr 1. J Am Chem Soc. 2015. PMID: 25785540 Free PMC article.

8

A fragmenting hybrid approach for targeted delivery of multiple therapeutic agents to the malaria parasite.

Mahajan SS, Deu E, Lauterwasser EM, Leyva MJ, Ellman JA, Bogyo M, Renslo AR. Mahajan SS, et al. Among authors: ellman ja. ChemMedChem. 2011 Mar 7;6(3):415-9. doi: 10.1002/cmdc.201100002. Epub 2011 Jan 24. ChemMedChem. 2011. PMID: 21360816 Free PMC article. No abstract available.

9

Definition of the extended substrate specificity determinants for beta-tryptases I and II.

Harris JL, Niles A, Burdick K, Maffitt M, Backes BJ, Ellman JA, Kuntz I, Haak-Frendscho M, Craik CS. Harris JL, et al. Among authors: ellman ja. J Biol Chem. 2001 Sep 14;276(37):34941-7. doi: 10.1074/jbc.M102997200. Epub 2001 Jul 3. J Biol Chem. 2001. PMID: 11438529 Free article.

10

Expedient solid-phase synthesis of fluorogenic protease substrates using the 7-amino-4-carbamoylmethylcoumarin (ACC) fluorophore.

Maly DJ, Leonetti F, Backes BJ, Dauber DS, Harris JL, Craik CS, Ellman JA. Maly DJ, et al. Among authors: ellman ja. J Org Chem. 2002 Feb 8;67(3):910-5. doi: 10.1021/jo016140o. J Org Chem. 2002. PMID: 11856036

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