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Page 1
Preclinical development of AMG 139, a human antibody specifically targeting IL-23.
Köck K, Pan WJ, Gow JM, Horner MJ, Gibbs JP, Colbert A, Goletz TJ, Newhall KJ, Rees WA, Sun Y, Zhang Y, O'Neill JC, Umble-Romero AN, Prokop SP, Krill CD, Som L, Buntich SA, Trimble MW, Tsuji WH, Towne JE. Köck K, et al. Among authors: rees wa. Br J Pharmacol. 2015 Jan;172(1):159-72. doi: 10.1111/bph.12904. Epub 2014 Dec 15. Br J Pharmacol. 2015. PMID: 25205227 Free PMC article.
Clinical pharmacology of AMG 181, a gut-specific human anti-α4β7 monoclonal antibody, for treating inflammatory bowel diseases.
Pan WJ, Köck K, Rees WA, Sullivan BA, Evangelista CM, Yen M, Andrews JM, Radford-Smith GL, Prince PJ, Reynhardt KO, Doherty DR, Patel SK, Krill CD, Zhou K, Shen J, Smith LE, Gow JM, Lee J, Treacy AM, Yu Z, Platt VM, Borie DC. Pan WJ, et al. Among authors: rees wa. Br J Clin Pharmacol. 2014 Dec;78(6):1315-33. doi: 10.1111/bcp.12418. Br J Clin Pharmacol. 2014. PMID: 24803302 Free PMC article. Clinical Trial.
Off-target platelet activation in macaques unique to a therapeutic monoclonal antibody.
Santostefano MJ, Kirchner J, Vissinga C, Fort M, Lear S, Pan WJ, Prince PJ, Hensley KM, Tran D, Rock D, Vargas HM, Narayanan P, Jawando R, Rees W, Reindel JF, Reynhardt K, Everds N. Santostefano MJ, et al. Toxicol Pathol. 2012 Aug;40(6):899-917. doi: 10.1177/0192623312444029. Epub 2012 May 2. Toxicol Pathol. 2012. PMID: 22552394
Pharmacology of AMG 181, a human anti-α4 β7 antibody that specifically alters trafficking of gut-homing T cells.
Pan WJ, Hsu H, Rees WA, Lear SP, Lee F, Foltz IN, Rathanaswami P, Manchulenko K, Chan BM, Zhang M, Xia XZ, Patel SK, Prince PJ, Doherty DR, Sheckler CM, Reynhardt KO, Krill CD, Harder BJ, Wisler JA, Brandvig JL, Lynch JL, Anderson AA, Wienkers LC, Borie DC. Pan WJ, et al. Among authors: rees wa. Br J Pharmacol. 2013 May;169(1):51-68. doi: 10.1111/bph.12134. Br J Pharmacol. 2013. PMID: 23425116 Free PMC article.
Efficacy and Safety of MEDI2070, an Antibody Against Interleukin 23, in Patients With Moderate to Severe Crohn's Disease: A Phase 2a Study.
Sands BE, Chen J, Feagan BG, Penney M, Rees WA, Danese S, Higgins PDR, Newbold P, Faggioni R, Patra K, Li J, Klekotka P, Morehouse C, Pulkstenis E, Drappa J, van der Merwe R, Gasser RA Jr. Sands BE, et al. Among authors: rees wa. Gastroenterology. 2017 Jul;153(1):77-86.e6. doi: 10.1053/j.gastro.2017.03.049. Epub 2017 Apr 5. Gastroenterology. 2017. PMID: 28390867 Free article. Clinical Trial.
44 results