Asada M - Search Results

1

3-(2-Aminocarbonylphenyl)propanoic acid analogs as potent and selective EP3 receptor antagonists. Part 1: discovery and exploration of the carboxyamide side chain.

Asada M, Obitsu T, Nagase T, Tanaka M, Yamaura Y, Takizawa H, Yoshikawa K, Sato K, Narita M, Ohuchida S, Nakai H, Toda M. Asada M, et al. Bioorg Med Chem. 2010 Jan 1;18(1):80-90. doi: 10.1016/j.bmc.2009.11.023. Epub 2009 Nov 12. Bioorg Med Chem. 2010. PMID: 20004584

2

Design and synthesis of a selective EP4-receptor agonist. Part 1: discovery of 3,7-dithiaPGE1 derivatives and identification of their omega chains.

Maruyama T, Asada M, Shiraishi T, Egashira H, Yoshida H, Maruyama T, Ohuchida S, Nakai H, Kondo K, Toda M. Maruyama T, et al. Among authors: asada m. Bioorg Med Chem. 2002 Apr;10(4):975-88. doi: 10.1016/s0968-0896(01)00351-0. Bioorg Med Chem. 2002. PMID: 11836107

3

Design and synthesis of a selective EP4-receptor agonist. Part 2: 3,7-dithiaPGE1 derivatives with high selectivity.

Maruyama T, Asada M, Shiraishi T, Ishida A, Yoshida H, Maruyama T, Ohuchida S, Nakai H, Kondo K, Toda M. Maruyama T, et al. Among authors: asada m. Bioorg Med Chem. 2002 Apr;10(4):989-1008. doi: 10.1016/s0968-0896(01)00352-2. Bioorg Med Chem. 2002. PMID: 11836108

4

Design and synthesis of a selective EP4-receptor agonist. Part 3: 16-phenyl-5-thiaPGE(1) and 9-beta-halo derivatives with improved stability.

Maruyama T, Asada M, Shiraishi T, Yoshida H, Maruyama T, Ohuchida S, Nakai H, Kondo K, Toda M. Maruyama T, et al. Among authors: asada m. Bioorg Med Chem. 2002 Jun;10(6):1743-59. doi: 10.1016/s0968-0896(02)00031-7. Bioorg Med Chem. 2002. PMID: 11937333

5

Discovery of a series of acrylic acids and their derivatives as chemical leads for selective EP3 receptor antagonists.

Asada M, Obitsu T, Nagase T, Sugimoto I, Yamaura Y, Sato K, Narita M, Ohuchida S, Nakai H, Toda M. Asada M, et al. Bioorg Med Chem. 2009 Sep 15;17(18):6567-82. doi: 10.1016/j.bmc.2009.08.007. Epub 2009 Aug 8. Bioorg Med Chem. 2009. PMID: 19700331

6

3-(2-Aminocarbonylphenyl)propanoic acid analogs as potent and selective EP3 receptor antagonists. part 2: optimization of the side chains to improve in vitro and in vivo potencies.

Asada M, Iwahashi M, Obitsu T, Kinoshita A, Nakai Y, Onoda T, Nagase T, Tanaka M, Yamaura Y, Takizawa H, Yoshikawa K, Sato K, Narita M, Ohuchida S, Nakai H, Toda M. Asada M, et al. Bioorg Med Chem. 2010 Feb 15;18(4):1641-58. doi: 10.1016/j.bmc.2009.12.068. Epub 2010 Jan 4. Bioorg Med Chem. 2010. PMID: 20129791

7

Discovery of novel N-acylsulfonamide analogs as potent and selective EP3 receptor antagonists.

Asada M, Obitsu T, Kinoshita A, Nakai Y, Nagase T, Sugimoto I, Tanaka M, Takizawa H, Yoshikawa K, Sato K, Narita M, Ohuchida S, Nakai H, Toda M. Asada M, et al. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2639-43. doi: 10.1016/j.bmcl.2010.02.034. Epub 2010 Feb 13. Bioorg Med Chem Lett. 2010. PMID: 20346663

8

3-(2-Aminocarbonylphenyl)propanoic acid analogs as potent and selective EP3 receptor antagonists. Part 3: Synthesis, metabolic stability, and biological evaluation of optically active analogs.

Asada M, Obitsu T, Kinoshita A, Nagase T, Yoshida T, Yamaura Y, Takizawa H, Yoshikawa K, Sato K, Narita M, Nakai H, Toda M, Tobe Y. Asada M, et al. Bioorg Med Chem. 2010 May 1;18(9):3212-23. doi: 10.1016/j.bmc.2010.03.028. Epub 2010 Mar 17. Bioorg Med Chem. 2010. PMID: 20385498

9

Design and synthesis of a highly selective EP4-receptor agonist. Part 1: 3,7-dithiaPG derivatives with high selectivity.

Maruyama T, Asada M, Shiraishi T, Ishida A, Egashira H, Yoshida H, Maruyama T, Ohuchida S, Nakai H, Kondo K, Toda M. Maruyama T, et al. Among authors: asada m. Bioorg Med Chem Lett. 2001 Aug 6;11(15):2029-31. doi: 10.1016/s0960-894x(01)00364-x. Bioorg Med Chem Lett. 2001. PMID: 11454473

10

Design and synthesis of a highly selective EP4-receptor agonist. Part 2: 5-thia and 9beta-haloPG derivatives with improved stability.

Maruyama T, Asada M, Shiraishi T, Sakata K, Seki A, Yoshida H, Shinagawa Y, Maruyama T, Ohuchida S, Nakai H, Kondo K, Toda M. Maruyama T, et al. Among authors: asada m. Bioorg Med Chem Lett. 2001 Aug 6;11(15):2033-5. doi: 10.1016/s0960-894x(01)00365-1. Bioorg Med Chem Lett. 2001. PMID: 11454474

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