Nagase T - Search Results

1

3-(2-Aminocarbonylphenyl)propanoic acid analogs as potent and selective EP3 receptor antagonists. Part 1: discovery and exploration of the carboxyamide side chain.

Asada M, Obitsu T, Nagase T, Tanaka M, Yamaura Y, Takizawa H, Yoshikawa K, Sato K, Narita M, Ohuchida S, Nakai H, Toda M. Asada M, et al. Among authors: nagase t. Bioorg Med Chem. 2010 Jan 1;18(1):80-90. doi: 10.1016/j.bmc.2009.11.023. Epub 2009 Nov 12. Bioorg Med Chem. 2010. PMID: 20004584

2

Discovery of orally active prostaglandin D2 receptor antagonists.

Torisu K, Kobayashi K, Iwahashi M, Nakai Y, Onoda T, Nagase T, Sugimoto I, Okada Y, Matsumoto R, Nanbu F, Ohuchida S, Nakai H, Toda M. Torisu K, et al. Among authors: nagase t. Bioorg Med Chem Lett. 2004 Oct 4;14(19):4891-5. doi: 10.1016/j.bmcl.2004.07.039. Bioorg Med Chem Lett. 2004. PMID: 15341946

3

Development of prostaglandin D2 receptor antagonist: discovery of highly potent antagonists.

Torisu K, Kobayashi K, Iwahashi M, Nakai Y, Onoda T, Nagase T, Sugimoto I, Okada Y, Matsumoto R, Nanbu F, Ohuchida S, Nakai H, Masaaki Toda. Torisu K, et al. Among authors: nagase t. Bioorg Med Chem. 2004 Sep 1;12(17):4685-700. doi: 10.1016/j.bmc.2004.06.024. Bioorg Med Chem. 2004. PMID: 15358295

4

Discovery of a new class of potent, selective, and orally active prostaglandin D2 receptor antagonists.

Torisu K, Kobayashi K, Iwahashi M, Nakai Y, Onoda T, Nagase T, Sugimoto I, Okada Y, Matsumoto R, Nanbu F, Ohuchida S, Nakai H, Toda M. Torisu K, et al. Among authors: nagase t. Bioorg Med Chem. 2004 Oct 15;12(20):5361-78. doi: 10.1016/j.bmc.2004.07.048. Bioorg Med Chem. 2004. PMID: 15388164

5

Discovery of a series of acrylic acids and their derivatives as chemical leads for selective EP3 receptor antagonists.

Asada M, Obitsu T, Nagase T, Sugimoto I, Yamaura Y, Sato K, Narita M, Ohuchida S, Nakai H, Toda M. Asada M, et al. Among authors: nagase t. Bioorg Med Chem. 2009 Sep 15;17(18):6567-82. doi: 10.1016/j.bmc.2009.08.007. Epub 2009 Aug 8. Bioorg Med Chem. 2009. PMID: 19700331

6

3-(2-Aminocarbonylphenyl)propanoic acid analogs as potent and selective EP3 receptor antagonists. part 2: optimization of the side chains to improve in vitro and in vivo potencies.

Asada M, Iwahashi M, Obitsu T, Kinoshita A, Nakai Y, Onoda T, Nagase T, Tanaka M, Yamaura Y, Takizawa H, Yoshikawa K, Sato K, Narita M, Ohuchida S, Nakai H, Toda M. Asada M, et al. Among authors: nagase t. Bioorg Med Chem. 2010 Feb 15;18(4):1641-58. doi: 10.1016/j.bmc.2009.12.068. Epub 2010 Jan 4. Bioorg Med Chem. 2010. PMID: 20129791

7

Discovery of novel N-acylsulfonamide analogs as potent and selective EP3 receptor antagonists.

Asada M, Obitsu T, Kinoshita A, Nakai Y, Nagase T, Sugimoto I, Tanaka M, Takizawa H, Yoshikawa K, Sato K, Narita M, Ohuchida S, Nakai H, Toda M. Asada M, et al. Among authors: nagase t. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2639-43. doi: 10.1016/j.bmcl.2010.02.034. Epub 2010 Feb 13. Bioorg Med Chem Lett. 2010. PMID: 20346663

8

3-(2-Aminocarbonylphenyl)propanoic acid analogs as potent and selective EP3 receptor antagonists. Part 3: Synthesis, metabolic stability, and biological evaluation of optically active analogs.

Asada M, Obitsu T, Kinoshita A, Nagase T, Yoshida T, Yamaura Y, Takizawa H, Yoshikawa K, Sato K, Narita M, Nakai H, Toda M, Tobe Y. Asada M, et al. Among authors: nagase t. Bioorg Med Chem. 2010 May 1;18(9):3212-23. doi: 10.1016/j.bmc.2010.03.028. Epub 2010 Mar 17. Bioorg Med Chem. 2010. PMID: 20385498

9

Synthesis and evaluation of novel modified γ-lactam prostanoids as EP4 subtype-selective agonists.

Kambe T, Maruyama T, Nagase T, Ogawa S, Minamoto C, Sakata K, Maruyama T, Nakai H, Toda M. Kambe T, et al. Among authors: nagase t. Bioorg Med Chem. 2012 Jan 15;20(2):702-13. doi: 10.1016/j.bmc.2011.12.009. Epub 2011 Dec 13. Bioorg Med Chem. 2012. PMID: 22204740

10

Inhibition of beta-lactamases by 6,6-bis(hydroxylmethyl)penicillanate.

Nagase T, Golemi D, Ishiwata A, Mobashery S. Nagase T, et al. Bioorg Chem. 2001 Jun;29(3):140-5. doi: 10.1006/bioo.2001.1205. Bioorg Chem. 2001. PMID: 11437389

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