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3-(2-Aminocarbonylphenyl)propanoic acid analogs as potent and selective EP3 receptor antagonists. part 2: optimization of the side chains to improve in vitro and in vivo potencies.
Asada M, Iwahashi M, Obitsu T, Kinoshita A, Nakai Y, Onoda T, Nagase T, Tanaka M, Yamaura Y, Takizawa H, Yoshikawa K, Sato K, Narita M, Ohuchida S, Nakai H, Toda M. Asada M, et al. Among authors: tanaka m. Bioorg Med Chem. 2010 Feb 15;18(4):1641-58. doi: 10.1016/j.bmc.2009.12.068. Epub 2010 Jan 4. Bioorg Med Chem. 2010. PMID: 20129791
Design and synthesis of new prostaglandin D₂ receptor antagonists.
Iwahashi M, Takahashi E, Tanaka M, Matsunaga Y, Okada Y, Matsumoto R, Nambu F, Nakai H, Toda M. Iwahashi M, et al. Among authors: tanaka m. Bioorg Med Chem. 2011 Sep 15;19(18):5361-71. doi: 10.1016/j.bmc.2011.08.007. Epub 2011 Aug 8. Bioorg Med Chem. 2011. PMID: 21885288
Discovery of a Slow Tight Binding LPA1 Antagonist (ONO-0300302) for the Treatment of Benign Prostatic Hyperplasia.
Terakado M, Suzuki H, Hashimura K, Tanaka M, Ueda H, Hirai K, Asada M, Ikura M, Matsunaga N, Saga H, Shinozaki K, Karakawa N, Takada Y, Minami M, Egashira H, Sugiura Y, Yamada M, Nakade S, Takaoka Y. Terakado M, et al. Among authors: tanaka m. ACS Med Chem Lett. 2017 Nov 20;8(12):1281-1286. doi: 10.1021/acsmedchemlett.7b00383. eCollection 2017 Dec 14. ACS Med Chem Lett. 2017. PMID: 29259748 Free PMC article.
Discovery and SAR Studies of Orally Active Somatostatin Receptor Subtype-2 (SSTR2) Agonists for the Treatment of Acromegaly.
Ishida A, Tajima Y, Okabe Y, Matsushita T, Sekiguchi T, Imaide S, Nomura Y, Tanaka M, Nojima S, Yoshida A, Iyoda Y, Aoki S, Nishio T, Komagata T, Iwaki M, Shono T, Naganawa A, Imagawa A. Ishida A, et al. Among authors: tanaka m. ACS Chem Neurosci. 2020 May 20;11(10):1482-1494. doi: 10.1021/acschemneuro.0c00124. Epub 2020 May 1. ACS Chem Neurosci. 2020. PMID: 32315148
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