Lane H - Search Results

1

Specific apoptosis induction by the dual PI3K/mTor inhibitor NVP-BEZ235 in HER2 amplified and PIK3CA mutant breast cancer cells.

Brachmann SM, Hofmann I, Schnell C, Fritsch C, Wee S, Lane H, Wang S, Garcia-Echeverria C, Maira SM. Brachmann SM, et al. Among authors: lane h. Proc Natl Acad Sci U S A. 2009 Dec 29;106(52):22299-304. doi: 10.1073/pnas.0905152106. Epub 2009 Dec 10. Proc Natl Acad Sci U S A. 2009. PMID: 20007781 Free PMC article.

2

mTOR inhibitor RAD001 (everolimus) has antiangiogenic/vascular properties distinct from a VEGFR tyrosine kinase inhibitor.

Lane HA, Wood JM, McSheehy PM, Allegrini PR, Boulay A, Brueggen J, Littlewood-Evans A, Maira SM, Martiny-Baron G, Schnell CR, Sini P, O'Reilly T. Lane HA, et al. Clin Cancer Res. 2009 Mar 1;15(5):1612-22. doi: 10.1158/1078-0432.CCR-08-2057. Epub 2009 Feb 17. Clin Cancer Res. 2009. PMID: 19223496

3

Dual Inhibition of the Lactate Transporters MCT1 and MCT4 Is Synthetic Lethal with Metformin due to NAD+ Depletion in Cancer Cells.

Benjamin D, Robay D, Hindupur SK, Pohlmann J, Colombi M, El-Shemerly MY, Maira SM, Moroni C, Lane HA, Hall MN. Benjamin D, et al. Cell Rep. 2018 Dec 11;25(11):3047-3058.e4. doi: 10.1016/j.celrep.2018.11.043. Cell Rep. 2018. PMID: 30540938 Free PMC article.

4

Everolimus and PTK/ZK show synergistic growth inhibition in the orthotopic BL16/BL6 murine melanoma model.

O'Reilly T, Lane HA, Wood JM, Schnell C, Littlewood-Evans A, Brueggen J, McSheehy PM. O'Reilly T, et al. Cancer Chemother Pharmacol. 2011 Jan;67(1):193-200. doi: 10.1007/s00280-010-1307-z. Epub 2010 May 30. Cancer Chemother Pharmacol. 2011. PMID: 20512579

5

Minimally invasive biomarkers for therapy monitoring.

McSheehy P, Allegrini P, Ametaby S, Becquet M, Ebenhan T, Honer M, Ferretti S, Lane H, Schubiger P, Schnell C, Stumm M, Wood J. McSheehy P, et al. Among authors: lane h. Ernst Schering Found Symp Proc. 2007;(4):153-88. doi: 10.1007/2789_2008_093. Ernst Schering Found Symp Proc. 2007. PMID: 18811057

6

Dual inhibition of mTOR and estrogen receptor signaling in vitro induces cell death in models of breast cancer.

Boulay A, Rudloff J, Ye J, Zumstein-Mecker S, O'Reilly T, Evans DB, Chen S, Lane HA. Boulay A, et al. Clin Cancer Res. 2005 Jul 15;11(14):5319-28. doi: 10.1158/1078-0432.CCR-04-2402. Clin Cancer Res. 2005. PMID: 16033851

7

Increased AKT S473 phosphorylation after mTORC1 inhibition is rictor dependent and does not predict tumor cell response to PI3K/mTOR inhibition.

Breuleux M, Klopfenstein M, Stephan C, Doughty CA, Barys L, Maira SM, Kwiatkowski D, Lane HA. Breuleux M, et al. Mol Cancer Ther. 2009 Apr;8(4):742-53. doi: 10.1158/1535-7163.MCT-08-0668. Mol Cancer Ther. 2009. PMID: 19372546 Free PMC article.

8

The mTOR inhibitor RAD001 sensitizes tumor cells to DNA-damaged induced apoptosis through inhibition of p21 translation.

Beuvink I, Boulay A, Fumagalli S, Zilbermann F, Ruetz S, O'Reilly T, Natt F, Hall J, Lane HA, Thomas G. Beuvink I, et al. Cell. 2005 Mar 25;120(6):747-59. doi: 10.1016/j.cell.2004.12.040. Cell. 2005. PMID: 15797377 Free article.

9

AKT/mTOR pathway activation and BCL-2 family proteins modulate the sensitivity of human small cell lung cancer cells to RAD001.

Marinov M, Ziogas A, Pardo OE, Tan LT, Dhillon T, Mauri FA, Lane HA, Lemoine NR, Zangemeister-Wittke U, Seckl MJ, Arcaro A. Marinov M, et al. Clin Cancer Res. 2009 Feb 15;15(4):1277-87. doi: 10.1158/1078-0432.CCR-08-2166. Clin Cancer Res. 2009. PMID: 19228731 Free article.

10

The role of overexpressed HER2 in transformation.

Neve RM, Lane HA, Hynes NE. Neve RM, et al. Among authors: lane ha. Ann Oncol. 2001;12 Suppl 1:S9-13. doi: 10.1093/annonc/12.suppl_1.s9. Ann Oncol. 2001. PMID: 11521729 Free article. Review.

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