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Pharmacological properties of S1RA, a new sigma-1 receptor antagonist that inhibits neuropathic pain and activity-induced spinal sensitization.
Romero L, Zamanillo D, Nadal X, Sánchez-Arroyos R, Rivera-Arconada I, Dordal A, Montero A, Muro A, Bura A, Segalés C, Laloya M, Hernández E, Portillo-Salido E, Escriche M, Codony X, Encina G, Burgueño J, Merlos M, Baeyens JM, Giraldo J, López-García JA, Maldonado R, Plata-Salamán CR, Vela JM. Romero L, et al. Among authors: vela jm. Br J Pharmacol. 2012 Aug;166(8):2289-306. doi: 10.1111/j.1476-5381.2012.01942.x. Br J Pharmacol. 2012. PMID: 22404321 Free PMC article.
Synthesis and biological evaluation of the 1-arylpyrazole class of σ(1) receptor antagonists: identification of 4-{2-[5-methyl-1-(naphthalen-2-yl)-1H-pyrazol-3-yloxy]ethyl}morpholine (S1RA, E-52862).
Díaz JL, Cuberes R, Berrocal J, Contijoch M, Christmann U, Fernández A, Port A, Holenz J, Buschmann H, Laggner C, Serafini MT, Burgueño J, Zamanillo D, Merlos M, Vela JM, Almansa C. Díaz JL, et al. Among authors: vela jm. J Med Chem. 2012 Oct 11;55(19):8211-24. doi: 10.1021/jm3007323. Epub 2012 Jul 27. J Med Chem. 2012. PMID: 22784008
Sigma 1 receptor: a new therapeutic target for pain.
Zamanillo D, Romero L, Merlos M, Vela JM. Zamanillo D, et al. Among authors: vela jm. Eur J Pharmacol. 2013 Sep 15;716(1-3):78-93. doi: 10.1016/j.ejphar.2013.01.068. Epub 2013 Mar 13. Eur J Pharmacol. 2013. PMID: 23500210 Review.
Sigma-1 receptor antagonism as opioid adjuvant strategy: enhancement of opioid antinociception without increasing adverse effects.
Vidal-Torres A, de la Puente B, Rocasalbas M, Touriño C, Bura SA, Fernández-Pastor B, Romero L, Codony X, Zamanillo D, Buschmann H, Merlos M, Baeyens JM, Maldonado R, Vela JM. Vidal-Torres A, et al. Among authors: vela jm. Eur J Pharmacol. 2013 Jul 5;711(1-3):63-72. doi: 10.1016/j.ejphar.2013.04.018. Epub 2013 Apr 28. Eur J Pharmacol. 2013. PMID: 23632394
Sigma-1 Receptor and Pain.
Merlos M, Romero L, Zamanillo D, Plata-Salamán C, Vela JM. Merlos M, et al. Among authors: vela jm. Handb Exp Pharmacol. 2017;244:131-161. doi: 10.1007/164_2017_9. Handb Exp Pharmacol. 2017. PMID: 28275913 Review.
EST64454: a Highly Soluble σ1 Receptor Antagonist Clinical Candidate for Pain Management.
Díaz JL, García M, Torrens A, Caamaño AM, Enjo J, Sicre C, Lorente A, Port A, Montero A, Yeste S, Álvarez I, Martín M, Maldonado R, de la Puente B, Vidal-Torres A, Cendán CM, Vela JM, Almansa C. Díaz JL, et al. Among authors: vela jm. J Med Chem. 2020 Dec 10;63(23):14979-14988. doi: 10.1021/acs.jmedchem.0c01575. Epub 2020 Nov 25. J Med Chem. 2020. PMID: 33237785
Tricyclic Triazoles as σ1 Receptor Antagonists for Treating Pain.
Díaz JL, Cuevas F, Oliva AI, Font D, Sarmentero MÁ, Álvarez-Bercedo P, López-Valbuena JM, Pericàs MA, Enrech R, Montero A, Yeste S, Vidal-Torres A, Álvarez I, Pérez P, Cendán CM, Cobos EJ, Vela JM, Almansa C. Díaz JL, et al. Among authors: vela jm. J Med Chem. 2021 Apr 22;64(8):5157-5170. doi: 10.1021/acs.jmedchem.1c00244. Epub 2021 Apr 7. J Med Chem. 2021. PMID: 33826322
125 results