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The C-terminal tail of CRTH2 is a key molecular determinant that constrains Galphai and downstream signaling cascade activation.
Schröder R, Merten N, Mathiesen JM, Martini L, Kruljac-Letunic A, Krop F, Blaukat A, Fang Y, Tran E, Ulven T, Drewke C, Whistler J, Pardo L, Gomeza J, Kostenis E. Schröder R, et al. Among authors: mathiesen jm. J Biol Chem. 2009 Jan 9;284(2):1324-36. doi: 10.1074/jbc.M806867200. Epub 2008 Nov 14. J Biol Chem. 2009. PMID: 19010788 Free article.
1,2,3-triazolyl amino acids as AMPA receptor ligands.
Stanley NJ, Pedersen DS, Nielsen B, Kvist T, Mathiesen JM, Bräuner-Osborne H, Taylor DK, Abell AD. Stanley NJ, et al. Among authors: mathiesen jm. Bioorg Med Chem Lett. 2010 Dec 15;20(24):7512-5. doi: 10.1016/j.bmcl.2010.09.139. Epub 2010 Oct 14. Bioorg Med Chem Lett. 2010. PMID: 21036612
A new metabotropic glutamate receptor agonist with in vivo anti-allodynic activity.
Stanley NJ, Hutchinson MR, Kvist T, Nielsen B, Mathiesen JM, Bräuner-Osborne H, Avery TD, Tiekink ER, Pedersen DS, Irvine RJ, Abell AD, Taylor DK. Stanley NJ, et al. Among authors: mathiesen jm. Bioorg Med Chem. 2010 Aug 15;18(16):6089-98. doi: 10.1016/j.bmc.2010.06.051. Epub 2010 Jun 25. Bioorg Med Chem. 2010. PMID: 20638290
46 results