Patterson PH - Search Results

1

IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome.

Thompson LM, Aiken CT, Kaltenbach LS, Agrawal N, Illes K, Khoshnan A, Martinez-Vincente M, Arrasate M, O'Rourke JG, Khashwji H, Lukacsovich T, Zhu YZ, Lau AL, Massey A, Hayden MR, Zeitlin SO, Finkbeiner S, Green KN, LaFerla FM, Bates G, Huang L, Patterson PH, Lo DC, Cuervo AM, Marsh JL, Steffan JS. Thompson LM, et al. Among authors: patterson ph. J Cell Biol. 2009 Dec 28;187(7):1083-99. doi: 10.1083/jcb.200909067. Epub 2009 Dec 21. J Cell Biol. 2009. PMID: 20026656 Free PMC article.

2

Effects of intracellular expression of anti-huntingtin antibodies of various specificities on mutant huntingtin aggregation and toxicity.

Khoshnan A, Ko J, Patterson PH. Khoshnan A, et al. Among authors: patterson ph. Proc Natl Acad Sci U S A. 2002 Jan 22;99(2):1002-7. doi: 10.1073/pnas.022631799. Epub 2002 Jan 15. Proc Natl Acad Sci U S A. 2002. PMID: 11792860 Free PMC article.

3

Antibodies against huntingtin: production and screening of monoclonals and single-chain recombinant forms.

Khoshnan A, Ou S, Ko J, Patterson PH. Khoshnan A, et al. Among authors: patterson ph. Methods Mol Biol. 2004;277:87-102. doi: 10.1385/1-59259-804-8:087. Methods Mol Biol. 2004. PMID: 15201451

4

Intrabodies binding the proline-rich domains of mutant huntingtin increase its turnover and reduce neurotoxicity.

Southwell AL, Khoshnan A, Dunn DE, Bugg CW, Lo DC, Patterson PH. Southwell AL, et al. Among authors: patterson ph. J Neurosci. 2008 Sep 3;28(36):9013-20. doi: 10.1523/JNEUROSCI.2747-08.2008. J Neurosci. 2008. PMID: 18768695 Free PMC article.

5

IKKalpha and IKKbeta regulation of DNA damage-induced cleavage of huntingtin.

Khoshnan A, Ko J, Tescu S, Brundin P, Patterson PH. Khoshnan A, et al. Among authors: patterson ph. PLoS One. 2009 Jun 2;4(6):e5768. doi: 10.1371/journal.pone.0005768. PLoS One. 2009. PMID: 19488402 Free PMC article.

6

Perturbation with intrabodies reveals that calpain cleavage is required for degradation of huntingtin exon 1.

Southwell AL, Bugg CW, Kaltenbach LS, Dunn D, Butland S, Weiss A, Paganetti P, Lo DC, Patterson PH. Southwell AL, et al. Among authors: patterson ph. PLoS One. 2011 Jan 31;6(1):e16676. doi: 10.1371/journal.pone.0016676. PLoS One. 2011. PMID: 21304966 Free PMC article.

7

The role of IκB kinase complex in the neurobiology of Huntington's disease.

Khoshnan A, Patterson PH. Khoshnan A, et al. Among authors: patterson ph. Neurobiol Dis. 2011 Aug;43(2):305-11. doi: 10.1016/j.nbd.2011.04.015. Epub 2011 May 5. Neurobiol Dis. 2011. PMID: 21554955 Free PMC article. Review.

8

Antibodies and intrabodies against huntingtin: production and screening of monoclonals and single-chain recombinant forms.

Khoshnan A, Ou S, Ko J, Patterson PH. Khoshnan A, et al. Among authors: patterson ph. Methods Mol Biol. 2013;1010:231-51. doi: 10.1007/978-1-62703-411-1_15. Methods Mol Biol. 2013. PMID: 23754229

9

IKKβ and mutant huntingtin interactions regulate the expression of IL-34: implications for microglial-mediated neurodegeneration in HD.

Khoshnan A, Sabbaugh A, Calamini B, Marinero SA, Dunn DE, Yoo JH, Ko J, Lo DC, Patterson PH. Khoshnan A, et al. Among authors: patterson ph. Hum Mol Genet. 2017 Nov 1;26(21):4267-4277. doi: 10.1093/hmg/ddx315. Hum Mol Genet. 2017. PMID: 28973132 Free PMC article.

10

Activation of the IkappaB kinase complex and nuclear factor-kappaB contributes to mutant huntingtin neurotoxicity.

Khoshnan A, Ko J, Watkin EE, Paige LA, Reinhart PH, Patterson PH. Khoshnan A, et al. Among authors: patterson ph. J Neurosci. 2004 Sep 15;24(37):7999-8008. doi: 10.1523/JNEUROSCI.2675-04.2004. J Neurosci. 2004. PMID: 15371500 Free PMC article.

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