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Genetic evidence for a tumor suppressor role of HIF-2alpha.
Acker T, Diez-Juan A, Aragones J, Tjwa M, Brusselmans K, Moons L, Fukumura D, Moreno-Murciano MP, Herbert JM, Burger A, Riedel J, Elvert G, Flamme I, Maxwell PH, Collen D, Dewerchin M, Jain RK, Plate KH, Carmeliet P. Acker T, et al. Among authors: flamme i. Cancer Cell. 2005 Aug;8(2):131-41. doi: 10.1016/j.ccr.2005.07.003. Cancer Cell. 2005. PMID: 16098466 Free article.
Cooperative interaction of hypoxia-inducible factor-2alpha (HIF-2alpha ) and Ets-1 in the transcriptional activation of vascular endothelial growth factor receptor-2 (Flk-1).
Elvert G, Kappel A, Heidenreich R, Englmeier U, Lanz S, Acker T, Rauter M, Plate K, Sieweke M, Breier G, Flamme I. Elvert G, et al. Among authors: flamme i. J Biol Chem. 2003 Feb 28;278(9):7520-30. doi: 10.1074/jbc.M211298200. Epub 2002 Dec 2. J Biol Chem. 2003. PMID: 12464608 Free article.
PHD4 stimulates tumor angiogenesis in osteosarcoma cells via TGF-α.
Klotzsche-von Ameln A, Prade I, Grosser M, Kettelhake A, Rezaei M, Chavakis T, Flamme I, Wielockx B, Breier G. Klotzsche-von Ameln A, et al. Among authors: flamme i. Mol Cancer Res. 2013 Nov;11(11):1337-48. doi: 10.1158/1541-7786.MCR-13-0201. Epub 2013 Sep 18. Mol Cancer Res. 2013. PMID: 24048703
BAY 87-2243, a highly potent and selective inhibitor of hypoxia-induced gene activation has antitumor activities by inhibition of mitochondrial complex I.
Ellinghaus P, Heisler I, Unterschemmann K, Haerter M, Beck H, Greschat S, Ehrmann A, Summer H, Flamme I, Oehme F, Thierauch K, Michels M, Hess-Stumpp H, Ziegelbauer K. Ellinghaus P, et al. Among authors: flamme i. Cancer Med. 2013 Oct;2(5):611-24. doi: 10.1002/cam4.112. Epub 2013 Aug 20. Cancer Med. 2013. PMID: 24403227 Free PMC article.
44 results