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Page 1
Protective effect of human leukocyte antigen B27 in hepatitis C virus infection requires the presence of a genotype-specific immunodominant CD8+ T-cell epitope.
Neumann-Haefelin C, Timm J, Schmidt J, Kersting N, Fitzmaurice K, Oniangue-Ndza C, Kemper MN, Humphreys I, McKiernan S, Kelleher D, Lohmann V, Bowness P, Huzly D, Rosen HR, Kim AY, Lauer GM, Allen TM, Barnes E, Roggendorf M, Blum HE, Thimme R. Neumann-Haefelin C, et al. Among authors: oniangue ndza c. Hepatology. 2010 Jan;51(1):54-62. doi: 10.1002/hep.23275. Hepatology. 2010. PMID: 20034048 Free PMC article.
Escape from HLA-B*08-restricted CD8 T cells by hepatitis C virus is associated with fitness costs.
Salloum S, Oniangue-Ndza C, Neumann-Haefelin C, Hudson L, Giugliano S, aus dem Siepen M, Nattermann J, Spengler U, Lauer GM, Wiese M, Klenerman P, Bright H, Scherbaum N, Thimme R, Roggendorf M, Viazov S, Timm J. Salloum S, et al. Among authors: oniangue ndza c. J Virol. 2008 Dec;82(23):11803-12. doi: 10.1128/JVI.00997-08. Epub 2008 Sep 24. J Virol. 2008. PMID: 18815309 Free PMC article.
Compensatory mutations restore the replication defects caused by cytotoxic T lymphocyte escape mutations in hepatitis C virus polymerase.
Oniangue-Ndza C, Kuntzen T, Kemper M, Berical A, Wang YE, Neumann-Haefelin C, Foote PK, Hills-Evans K, Reyor LL, Kane K, Gladden AD, Bloom AK, Power KA, Thimme R, Lauer GM, Henn MR, Kim AY, Allen TM. Oniangue-Ndza C, et al. J Virol. 2011 Nov;85(22):11883-90. doi: 10.1128/JVI.00779-11. Epub 2011 Aug 31. J Virol. 2011. PMID: 21880756 Free PMC article.
Human leukocyte antigen B27 selects for rare escape mutations that significantly impair hepatitis C virus replication and require compensatory mutations.
Neumann-Haefelin C, Oniangue-Ndza C, Kuntzen T, Schmidt J, Nitschke K, Sidney J, Caillet-Saguy C, Binder M, Kersting N, Kemper MW, Power KA, Ingber S, Reyor LL, Hills-Evans K, Kim AY, Lauer GM, Lohmann V, Sette A, Henn MR, Bressanelli S, Thimme R, Allen TM. Neumann-Haefelin C, et al. Among authors: oniangue ndza c. Hepatology. 2011 Oct;54(4):1157-66. doi: 10.1002/hep.24541. Hepatology. 2011. PMID: 22006856 Free PMC article.
Structural and functional constraints limit options for cytotoxic T-lymphocyte escape in the immunodominant HLA-B27-restricted epitope in human immunodeficiency virus type 1 capsid.
Schneidewind A, Brockman MA, Sidney J, Wang YE, Chen H, Suscovich TJ, Li B, Adam RI, Allgaier RL, Mothé BR, Kuntzen T, Oniangue-Ndza C, Trocha A, Yu XG, Brander C, Sette A, Walker BD, Allen TM. Schneidewind A, et al. Among authors: oniangue ndza c. J Virol. 2008 Jun;82(11):5594-605. doi: 10.1128/JVI.02356-07. Epub 2008 Apr 2. J Virol. 2008. PMID: 18385228 Free PMC article.
Transmission and long-term stability of compensated CD8 escape mutations.
Schneidewind A, Brumme ZL, Brumme CJ, Power KA, Reyor LL, O'Sullivan K, Gladden A, Hempel U, Kuntzen T, Wang YE, Oniangue-Ndza C, Jessen H, Markowitz M, Rosenberg ES, Sékaly RP, Kelleher AD, Walker BD, Allen TM. Schneidewind A, et al. Among authors: oniangue ndza c. J Virol. 2009 Apr;83(8):3993-7. doi: 10.1128/JVI.01108-08. Epub 2008 Dec 17. J Virol. 2009. PMID: 19091871 Free PMC article.
HIV-1 adaptation to NK-cell-mediated immune pressure.
Alter G, Heckerman D, Schneidewind A, Fadda L, Kadie CM, Carlson JM, Oniangue-Ndza C, Martin M, Li B, Khakoo SI, Carrington M, Allen TM, Altfeld M. Alter G, et al. Among authors: oniangue ndza c. Nature. 2011 Aug 3;476(7358):96-100. doi: 10.1038/nature10237. Nature. 2011. PMID: 21814282 Free PMC article.