Systematic investigation of the effect of lyophilizate collapse on pharmaceutically relevant proteins, part 2: stability during storage at elevated temperatures.
Schersch K, Betz O, Garidel P, Muehlau S, Bassarab S, Winter G.
Schersch K, et al. Among authors: garidel p.
J Pharm Sci. 2012 Jul;101(7):2288-306. doi: 10.1002/jps.23121. Epub 2012 Apr 19.
J Pharm Sci. 2012.
PMID: 22517663
In the first part of this study, it was shown that collapse has no negative impact either on the properties of the freeze-dried cake or on protein stability [Schersch K, Betz O, Garidel P, Muehlau S, Bassarab S, Winter G. 2010. J Pharm Sci 99(5):2256-2278]. In order …
In the first part of this study, it was shown that collapse has no negative impact either on the properties of the freeze-dried cake or on p …