Frederick MO - Search Results

1

Involvement of caspase activation in azaspiracid-induced neurotoxicity in neocortical neurons.

Cao Z, LePage KT, Frederick MO, Nicolaou KC, Murray TF. Cao Z, et al. Among authors: frederick mo. Toxicol Sci. 2010 Apr;114(2):323-34. doi: 10.1093/toxsci/kfp312. Epub 2010 Jan 4. Toxicol Sci. 2010. PMID: 20047973 Free PMC article.

2

Cell volume decrease as a link between azaspiracid-induced cytotoxicity and c-Jun-N-terminal kinase activation in cultured neurons.

Vale C, Nicolaou KC, Frederick MO, Vieytes MR, Botana LM. Vale C, et al. Among authors: frederick mo. Toxicol Sci. 2010 Jan;113(1):158-68. doi: 10.1093/toxsci/kfp246. Epub 2009 Oct 8. Toxicol Sci. 2010. PMID: 19815690 Free PMC article.

3

Irreversible cytoskeletal disarrangement is independent of caspase activation during in vitro azaspiracid toxicity in human neuroblastoma cells.

Vilariño N, Nicolaou KC, Frederick MO, Vieytes MR, Botana LM. Vilariño N, et al. Among authors: frederick mo. Biochem Pharmacol. 2007 Jul 15;74(2):327-35. doi: 10.1016/j.bcp.2007.04.004. Epub 2007 Apr 7. Biochem Pharmacol. 2007. PMID: 17485074

4

Azaspiracid substituent at C1 is relevant to in vitro toxicity.

Vilariño N, Nicolaou KC, Frederick MO, Cagide E, Alfonso C, Alonso E, Vieytes MR, Botana LM. Vilariño N, et al. Among authors: frederick mo. Chem Res Toxicol. 2008 Sep;21(9):1823-31. doi: 10.1021/tx800165c. Epub 2008 Aug 16. Chem Res Toxicol. 2008. PMID: 18707138 Free PMC article.

5

Cell growth inhibition and actin cytoskeleton disorganization induced by azaspiracid-1 structure-activity studies.

Vilariño N, Nicolaou KC, Frederick MO, Cagide E, Ares IR, Louzao MC, Vieytes MR, Botana LM. Vilariño N, et al. Among authors: frederick mo. Chem Res Toxicol. 2006 Nov;19(11):1459-66. doi: 10.1021/tx060131z. Chem Res Toxicol. 2006. PMID: 17112233

6

Effects of azaspiracid-1, a potent cytotoxic agent, on primary neuronal cultures. A structure-activity relationship study.

Vale C, Nicolaou KC, Frederick MO, Gómez-Limia B, Alfonso A, Vieytes MR, Botana LM. Vale C, et al. Among authors: frederick mo. J Med Chem. 2007 Jan 25;50(2):356-63. doi: 10.1021/jm061063g. J Med Chem. 2007. PMID: 17228878

7

The c-Jun-N-terminal kinase is involved in the neurotoxic effect of azaspiracid-1.

Vale C, Gómez-Limia B, Nicolaou KC, Frederick MO, Vieytes MR, Botana LM. Vale C, et al. Among authors: frederick mo. Cell Physiol Biochem. 2007;20(6):957-66. doi: 10.1159/000110456. Cell Physiol Biochem. 2007. PMID: 17982278

8

Monoclonal antibodies with orthogonal azaspiracid epitopes.

Frederick MO, De Lamo Marin S, Janda KD, Nicolaou KC, Dickerson TJ. Frederick MO, et al. Chembiochem. 2009 Jul 6;10(10):1625-9. doi: 10.1002/cbic.200900201. Chembiochem. 2009. PMID: 19492388 Free PMC article.

9

Total synthesis and structural elucidation of azaspiracid-1. Final assignment and total synthesis of the correct structure of azaspiracid-1.

Nicolaou KC, Koftis TV, Vyskocil S, Petrovic G, Tang W, Frederick MO, Chen DY, Li Y, Ling T, Yamada YM. Nicolaou KC, et al. Among authors: frederick mo. J Am Chem Soc. 2006 Mar 8;128(9):2859-72. doi: 10.1021/ja054750q. J Am Chem Soc. 2006. PMID: 16506764

10

Cytotoxic effect of azaspiracid-2 and azaspiracid-2-methyl ester in cultured neurons: involvement of the c-Jun N-terminal kinase.

Vale C, Wandscheer C, Nicolaou KC, Frederick MO, Alfonso C, Vieytes MR, Botana LM. Vale C, et al. Among authors: frederick mo. J Neurosci Res. 2008 Oct;86(13):2952-62. doi: 10.1002/jnr.21731. J Neurosci Res. 2008. PMID: 18500761

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