Scharff MD - Search Results

1

A V region mutation in a phosphocholine-binding monoclonal antibody results in loss of antigen binding.

Kobrin BJ, Buhl S, Shulman MJ, Scharff MD. Kobrin BJ, et al. Among authors: scharff md. J Immunol. 1991 Mar 15;146(6):2017-20. J Immunol. 1991. PMID: 2005389

2

A well-differentiated B-cell line is permissive for somatic mutation of a transfected immunoglobulin heavy-chain gene.

Zhu M, Rabinowitz JL, Green NS, Kobrin BJ, Scharff MD. Zhu M, et al. Among authors: scharff md. Proc Natl Acad Sci U S A. 1995 Mar 28;92(7):2810-4. doi: 10.1073/pnas.92.7.2810. Proc Natl Acad Sci U S A. 1995. PMID: 7708729 Free PMC article.

3

Activation-induced cytidine deaminase turns on somatic hypermutation in hybridomas.

Martin A, Bardwell PD, Woo CJ, Fan M, Shulman MJ, Scharff MD. Martin A, et al. Among authors: scharff md. Nature. 2002 Feb 14;415(6873):802-6. doi: 10.1038/nature714. Epub 2002 Jan 30. Nature. 2002. PMID: 11823785

4

Complex regulation of somatic hypermutation by cis-acting sequences in the endogenous IgH gene in hybridoma cells.

Ronai D, Iglesias-Ussel MD, Fan M, Shulman MJ, Scharff MD. Ronai D, et al. Among authors: scharff md. Proc Natl Acad Sci U S A. 2005 Aug 16;102(33):11829-34. doi: 10.1073/pnas.0505449102. Epub 2005 Aug 8. Proc Natl Acad Sci U S A. 2005. PMID: 16087866 Free PMC article.

5

Immunoglobulin variable region hypermutation in hybrids derived from a pre-B- and a myeloma cell line.

Green NS, Rabinowitz JL, Zhu M, Kobrin BJ, Scharff MD. Green NS, et al. Among authors: scharff md. Proc Natl Acad Sci U S A. 1995 Jul 3;92(14):6304-8. doi: 10.1073/pnas.92.14.6304. Proc Natl Acad Sci U S A. 1995. PMID: 7603987 Free PMC article.

6

In vitro activation of a nonproductive immunoglobulin allele by a single base pair insertion.

Kobrin BJ, Schiff C, Zivion D, Scharff MD, Spira G. Kobrin BJ, et al. Among authors: scharff md. Hybridoma. 1994 Aug;13(4):257-61. doi: 10.1089/hyb.1994.13.257. Hybridoma. 1994. PMID: 7806247

7

The production of more useful monoclonal antibodies I. Modifications of the basic technology.

French D, Fischberg E, Buhl S, Scharff MD. French D, et al. Among authors: scharff md. Immunol Today. 1986 Nov;7(11):344-6. doi: 10.1016/0167-5699(86)90142-8. Immunol Today. 1986. PMID: 25291104

8

The use of Bcl-2 over-expression to stabilize hybridomas specific to the HERG potassium channel.

Sroubek J, Krishnan Y, Chinai J, Buhl S, Scharff MD, McDonald TV. Sroubek J, et al. Among authors: scharff md. J Immunol Methods. 2012 Jan 31;375(1-2):215-22. doi: 10.1016/j.jim.2011.10.014. Epub 2011 Nov 15. J Immunol Methods. 2012. PMID: 22107967 Free PMC article.

9

Variable-region-identical antibodies differing in isotype demonstrate differences in fine specificity and idiotype.

Torres M, May R, Scharff MD, Casadevall A. Torres M, et al. Among authors: scharff md. J Immunol. 2005 Feb 15;174(4):2132-42. doi: 10.4049/jimmunol.174.4.2132. J Immunol. 2005. PMID: 15699144

10

Identification of mutant monoclonal antibodies with increased antigen binding.

Pollock RR, French DL, Gefter ML, Scharff MD. Pollock RR, et al. Among authors: scharff md. Proc Natl Acad Sci U S A. 1988 Apr;85(7):2298-302. doi: 10.1073/pnas.85.7.2298. Proc Natl Acad Sci U S A. 1988. PMID: 3267219 Free PMC article.

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