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The receptor SIGIRR suppresses Th17 cell proliferation via inhibition of the interleukin-1 receptor pathway and mTOR kinase activation.
Gulen MF, Kang Z, Bulek K, Youzhong W, Kim TW, Chen Y, Altuntas CZ, Sass Bak-Jensen K, McGeachy MJ, Do JS, Xiao H, Delgoffe GM, Min B, Powell JD, Tuohy VK, Cua DJ, Li X. Gulen MF, et al. Immunity. 2010 Jan 29;32(1):54-66. doi: 10.1016/j.immuni.2009.12.003. Epub 2010 Jan 7. Immunity. 2010. PMID: 20060329 Free PMC article.
Inactivation of the enzyme GSK3α by the kinase IKKi promotes AKT-mTOR signaling pathway that mediates interleukin-1-induced Th17 cell maintenance.
Gulen MF, Bulek K, Xiao H, Yu M, Gao J, Sun L, Beurel E, Kaidanovich-Beilin O, Fox PL, DiCorleto PE, Wang JA, Qin J, Wald DN, Woodgett JR, Jope RS, Carman J, Dongre A, Li X. Gulen MF, et al. Immunity. 2012 Nov 16;37(5):800-12. doi: 10.1016/j.immuni.2012.08.019. Epub 2012 Nov 8. Immunity. 2012. PMID: 23142783 Free PMC article.
CNS autoimmune inflammation: RICK must NOD!
Kang Z, Gulen MF, Li X. Kang Z, et al. Among authors: gulen mf. Immunity. 2011 Jan 28;34(1):3-5. doi: 10.1016/j.immuni.2011.01.010. Immunity. 2011. PMID: 21272781 Free PMC article.
35 results