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Histone deacetylase and Cullin3-REN(KCTD11) ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation.
Canettieri G, Di Marcotullio L, Greco A, Coni S, Antonucci L, Infante P, Pietrosanti L, De Smaele E, Ferretti E, Miele E, Pelloni M, De Simone G, Pedone EM, Gallinari P, Giorgi A, Steinkühler C, Vitagliano L, Pedone C, Schinin ME, Screpanti I, Gulino A. Canettieri G, et al. Among authors: gulino a. Nat Cell Biol. 2010 Feb;12(2):132-42. doi: 10.1038/ncb2013. Epub 2010 Jan 17. Nat Cell Biol. 2010. PMID: 20081843
REN(KCTD11) is a suppressor of Hedgehog signaling and is deleted in human medulloblastoma.
Di Marcotullio L, Ferretti E, De Smaele E, Argenti B, Mincione C, Zazzeroni F, Gallo R, Masuelli L, Napolitano M, Maroder M, Modesti A, Giangaspero F, Screpanti I, Alesse E, Gulino A. Di Marcotullio L, et al. Among authors: gulino a. Proc Natl Acad Sci U S A. 2004 Jul 20;101(29):10833-8. doi: 10.1073/pnas.0400690101. Epub 2004 Jul 12. Proc Natl Acad Sci U S A. 2004. PMID: 15249678 Free PMC article.
An integrated approach identifies Nhlh1 and Insm1 as Sonic Hedgehog-regulated genes in developing cerebellum and medulloblastoma.
De Smaele E, Fragomeli C, Ferretti E, Pelloni M, Po A, Canettieri G, Coni S, Di Marcotullio L, Greco A, Moretti M, Di Rocco C, Pazzaglia S, Maroder M, Screpanti I, Giannini G, Gulino A. De Smaele E, et al. Among authors: gulino a. Neoplasia. 2008 Jan;10(1):89-98. doi: 10.1593/neo.07891. Neoplasia. 2008. PMID: 18231642 Free PMC article.
The multiple functions of Numb.
Gulino A, Di Marcotullio L, Screpanti I. Gulino A, et al. Exp Cell Res. 2010 Apr 1;316(6):900-6. doi: 10.1016/j.yexcr.2009.11.017. Epub 2009 Nov 26. Exp Cell Res. 2010. PMID: 19944684 Review.
421 results