Clarke AR - Search Results

1

Genetic dissection of differential signaling threshold requirements for the Wnt/beta-catenin pathway in vivo.

Buchert M, Athineos D, Abud HE, Burke ZD, Faux MC, Samuel MS, Jarnicki AG, Winbanks CE, Newton IP, Meniel VS, Suzuki H, Stacker SA, Näthke IS, Tosh D, Huelsken J, Clarke AR, Heath JK, Sansom OJ, Ernst M. Buchert M, et al. Among authors: clarke ar. PLoS Genet. 2010 Jan 15;6(1):e1000816. doi: 10.1371/journal.pgen.1000816. PLoS Genet. 2010. PMID: 20084116 Free PMC article.

2

Spatiotemporal regulation of liver development by the Wnt/β-catenin pathway.

Burke ZD, Reed KR, Yeh SW, Meniel V, Sansom OJ, Clarke AR, Tosh D. Burke ZD, et al. Among authors: clarke ar. Sci Rep. 2018 Feb 9;8(1):2735. doi: 10.1038/s41598-018-20888-y. Sci Rep. 2018. PMID: 29426940 Free PMC article.

3

Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration.

Sansom OJ, Reed KR, Hayes AJ, Ireland H, Brinkmann H, Newton IP, Batlle E, Simon-Assmann P, Clevers H, Nathke IS, Clarke AR, Winton DJ. Sansom OJ, et al. Among authors: clarke ar. Genes Dev. 2004 Jun 15;18(12):1385-90. doi: 10.1101/gad.287404. Genes Dev. 2004. PMID: 15198980 Free PMC article.

4

B-catenin deficiency, but not Myc deletion, suppresses the immediate phenotypes of APC loss in the liver.

Reed KR, Athineos D, Meniel VS, Wilkins JA, Ridgway RA, Burke ZD, Muncan V, Clarke AR, Sansom OJ. Reed KR, et al. Among authors: clarke ar. Proc Natl Acad Sci U S A. 2008 Dec 2;105(48):18919-23. doi: 10.1073/pnas.0805778105. Epub 2008 Nov 24. Proc Natl Acad Sci U S A. 2008. PMID: 19033191 Free PMC article.

5

Liver zonation occurs through a beta-catenin-dependent, c-Myc-independent mechanism.

Burke ZD, Reed KR, Phesse TJ, Sansom OJ, Clarke AR, Tosh D. Burke ZD, et al. Among authors: clarke ar. Gastroenterology. 2009 Jun;136(7):2316-2324.e1-3. doi: 10.1053/j.gastro.2009.02.063. Epub 2009 Mar 5. Gastroenterology. 2009. PMID: 19268669

6

Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis.

Dikovskaya D, Schiffmann D, Newton IP, Oakley A, Kroboth K, Sansom O, Jamieson TJ, Meniel V, Clarke A, Näthke IS. Dikovskaya D, et al. J Cell Biol. 2007 Jan 15;176(2):183-95. doi: 10.1083/jcb.200610099. J Cell Biol. 2007. PMID: 17227893 Free PMC article.

7

Wnt-cadherin connections in normal and neoplastic mammary epithelium.

Meniel V, Clarke AR. Meniel V, et al. Among authors: clarke ar. J Mammary Gland Biol Neoplasia. 2003 Oct;8(4):435-47. doi: 10.1023/B:JOMG.0000017430.12210.37. J Mammary Gland Biol Neoplasia. 2003. PMID: 14985639 Review.

8

A limited role for p53 in modulating the immediate phenotype of Apc loss in the intestine.

Reed KR, Meniel VS, Marsh V, Cole A, Sansom OJ, Clarke AR. Reed KR, et al. Among authors: clarke ar. BMC Cancer. 2008 Jun 5;8:162. doi: 10.1186/1471-2407-8-162. BMC Cancer. 2008. PMID: 18533991 Free PMC article.

9

Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling.

Ashton GH, Morton JP, Myant K, Phesse TJ, Ridgway RA, Marsh V, Wilkins JA, Athineos D, Muncan V, Kemp R, Neufeld K, Clevers H, Brunton V, Winton DJ, Wang X, Sears RC, Clarke AR, Frame MC, Sansom OJ. Ashton GH, et al. Among authors: clarke ar. Dev Cell. 2010 Aug 17;19(2):259-69. doi: 10.1016/j.devcel.2010.07.015. Dev Cell. 2010. PMID: 20708588 Free PMC article.

10

Loss of Apc allows phenotypic manifestation of the transforming properties of an endogenous K-ras oncogene in vivo.

Sansom OJ, Meniel V, Wilkins JA, Cole AM, Oien KA, Marsh V, Jamieson TJ, Guerra C, Ashton GH, Barbacid M, Clarke AR. Sansom OJ, et al. Among authors: clarke ar. Proc Natl Acad Sci U S A. 2006 Sep 19;103(38):14122-7. doi: 10.1073/pnas.0604130103. Epub 2006 Sep 7. Proc Natl Acad Sci U S A. 2006. PMID: 16959882 Free PMC article.

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