Kaplan J - Search Results

1

Pyrazolopyrimidines as highly potent and selective, ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR): optimization of the 1-substituent.

Curran KJ, Verheijen JC, Kaplan J, Richard DJ, Toral-Barza L, Hollander I, Lucas J, Ayral-Kaloustian S, Yu K, Zask A. Curran KJ, et al. Among authors: kaplan j. Bioorg Med Chem Lett. 2010 Feb 15;20(4):1440-4. doi: 10.1016/j.bmcl.2009.12.086. Epub 2010 Jan 4. Bioorg Med Chem Lett. 2010. PMID: 20089401

2

D-piece modifications of the hemiasterlin analog HTI-286 produce potent tubulin inhibitors.

Zask A, Birnberg G, Cheung K, Kaplan J, Niu C, Norton E, Yamashita A, Beyer C, Krishnamurthy G, Greenberger LM, Loganzo F, Ayral-Kaloustian S. Zask A, et al. Among authors: kaplan j. Bioorg Med Chem Lett. 2004 Aug 16;14(16):4353-8. doi: 10.1016/j.bmcl.2004.05.005. Bioorg Med Chem Lett. 2004. PMID: 15261301

3

Probing the interaction of HTI-286 with tubulin using a stilbene analogue.

Lo MC, Aulabaugh A, Krishnamurthy G, Kaplan J, Zask A, Smith RP, Ellestad G. Lo MC, et al. Among authors: kaplan j. J Am Chem Soc. 2004 Aug 18;126(32):9898-9. doi: 10.1021/ja048619e. J Am Chem Soc. 2004. PMID: 15303845

4

Synthesis and biological activity of analogues of the antimicrotubule agent N,beta,beta-trimethyl-L-phenylalanyl-N(1)-[(1S,2E)-3-carboxy-1-isopropylbut-2-enyl]- N(1),3-dimethyl-L-valinamide (HTI-286).

Zask A, Birnberg G, Cheung K, Kaplan J, Niu C, Norton E, Suayan R, Yamashita A, Cole D, Tang Z, Krishnamurthy G, Williamson R, Khafizova G, Musto S, Hernandez R, Annable T, Yang X, Discafani C, Beyer C, Greenberger LM, Loganzo F, Ayral-Kaloustian S. Zask A, et al. Among authors: kaplan j. J Med Chem. 2004 Sep 9;47(19):4774-86. doi: 10.1021/jm040056u. J Med Chem. 2004. PMID: 15341492

5

Synthesis and activity of novel analogs of hemiasterlin as inhibitors of tubulin polymerization: modification of the A segment.

Yamashita A, Norton EB, Kaplan JA, Niu C, Loganzo F, Hernandez R, Beyer CF, Annable T, Musto S, Discafani C, Zask A, Ayral-Kaloustian S. Yamashita A, et al. Bioorg Med Chem Lett. 2004 Nov 1;14(21):5317-22. doi: 10.1016/j.bmcl.2004.08.024. Bioorg Med Chem Lett. 2004. PMID: 15454219

6

Cells resistant to HTI-286 do not overexpress P-glycoprotein but have reduced drug accumulation and a point mutation in alpha-tubulin.

Loganzo F, Hari M, Annable T, Tan X, Morilla DB, Musto S, Zask A, Kaplan J, Minnick AA Jr, May MK, Ayral-Kaloustian S, Poruchynsky MS, Fojo T, Greenberger LM. Loganzo F, et al. Among authors: kaplan j. Mol Cancer Ther. 2004 Oct;3(10):1319-27. Mol Cancer Ther. 2004. PMID: 15486199

7

Synthesis and SAR of diazepine and thiazepine TACE and MMP inhibitors.

Zask A, Kaplan J, Du X, MacEwan G, Sandanayaka V, Eudy N, Levin J, Jin G, Xu J, Cummons T, Barone D, Ayral-Kaloustian S, Skotnicki J. Zask A, et al. Among authors: kaplan j. Bioorg Med Chem Lett. 2005 Mar 15;15(6):1641-5. doi: 10.1016/j.bmcl.2005.01.053. Bioorg Med Chem Lett. 2005. PMID: 15745814

8

Two photoaffinity analogues of the tripeptide, hemiasterlin, exclusively label alpha-tubulin.

Nunes M, Kaplan J, Wooters J, Hari M, Minnick AA Jr, May MK, Shi C, Musto S, Beyer C, Krishnamurthy G, Qiu Y, Loganzo F, Ayral-Kaloustian S, Zask A, Greenberger LM. Nunes M, et al. Among authors: kaplan j. Biochemistry. 2005 May 10;44(18):6844-57. doi: 10.1021/bi0474766. Biochemistry. 2005. PMID: 15865430

9

Hybrids of the hemiasterlin analogue taltobulin and the dolastatins are potent antimicrotubule agents.

Zask A, Kaplan J, Musto S, Loganzo F. Zask A, et al. Among authors: kaplan j. J Am Chem Soc. 2005 Dec 21;127(50):17667-71. doi: 10.1021/ja053663v. J Am Chem Soc. 2005. PMID: 16351096

10

Synthesis and structure-activity relationships of ring-opened 17-hydroxywortmannins: potent phosphoinositide 3-kinase inhibitors with improved properties and anticancer efficacy.

Zask A, Kaplan J, Toral-Barza L, Hollander I, Young M, Tischler M, Gaydos C, Cinque M, Lucas J, Yu K. Zask A, et al. Among authors: kaplan j. J Med Chem. 2008 Mar 13;51(5):1319-23. doi: 10.1021/jm7012858. Epub 2008 Feb 13. J Med Chem. 2008. PMID: 18269228

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