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The future of non-human primate use in mAb development.
Chapman KL, Pullen N, Andrews L, Ragan I. Chapman KL, et al. Among authors: ragan i. Drug Discov Today. 2010 Mar;15(5-6):235-42. doi: 10.1016/j.drudis.2010.01.002. Epub 2010 Jan 21. Drug Discov Today. 2010. PMID: 20096369 Review.
Recommendations from a global cross-company data sharing initiative on the incorporation of recovery phase animals in safety assessment studies to support first-in-human clinical trials.
Sewell F, Chapman K, Baldrick P, Brewster D, Broadmeadow A, Brown P, Burns-Naas LA, Clarke J, Constan A, Couch J, Czupalla O, Danks A, DeGeorge J, de Haan L, Hettinger K, Hill M, Festag M, Jacobs A, Jacobson-Kram D, Kopytek S, Lorenz H, Moesgaard SG, Moore E, Pasanen M, Perry R, Ragan I, Robinson S, Schmitt PM, Short B, Lima BS, Smith D, Sparrow S, van Bekkum Y, Jones D. Sewell F, et al. Among authors: ragan i. Regul Toxicol Pharmacol. 2014 Oct;70(1):413-29. doi: 10.1016/j.yrtph.2014.07.018. Epub 2014 Jul 29. Regul Toxicol Pharmacol. 2014. PMID: 25078890 Free article.
Applying the 3Rs to non-human primate research: Barriers and solutions.
Prescott MJ, Langermans JA, Ragan I. Prescott MJ, et al. Among authors: ragan i. Drug Discov Today Dis Models. 2017 Spring;23:51-56. doi: 10.1016/j.ddmod.2017.11.001. Epub 2017 Nov 21. Drug Discov Today Dis Models. 2017. PMID: 33777153 Free PMC article.
Opportunities for improving animal welfare in rodent models of epilepsy and seizures.
Lidster K, Jefferys JG, Blümcke I, Crunelli V, Flecknell P, Frenguelli BG, Gray WP, Kaminski R, Pitkänen A, Ragan I, Shah M, Simonato M, Trevelyan A, Volk H, Walker M, Yates N, Prescott MJ. Lidster K, et al. Among authors: ragan i. J Neurosci Methods. 2016 Feb 15;260:2-25. doi: 10.1016/j.jneumeth.2015.09.007. Epub 2015 Sep 12. J Neurosci Methods. 2016. PMID: 26376175 Free article. Review.
A global initiative to refine acute inhalation studies through the use of 'evident toxicity' as an endpoint: Towards adoption of the fixed concentration procedure.
Sewell F, Ragan I, Marczylo T, Anderson B, Braun A, Casey W, Dennison N, Griffiths D, Guest R, Holmes T, van Huygevoort T, Indans I, Kenny T, Kojima H, Lee K, Prieto P, Smith P, Smedley J, Stokes WS, Wnorowski G, Horgan G. Sewell F, et al. Among authors: ragan i. Regul Toxicol Pharmacol. 2015 Dec;73(3):770-9. doi: 10.1016/j.yrtph.2015.10.018. Epub 2015 Oct 23. Regul Toxicol Pharmacol. 2015. PMID: 26505531 Free article.
52 results