Pires IM - Search Results

1

Effects of acute versus chronic hypoxia on DNA damage responses and genomic instability.

Pires IM, Bencokova Z, Milani M, Folkes LK, Li JL, Stratford MR, Harris AL, Hammond EM. Pires IM, et al. Cancer Res. 2010 Feb 1;70(3):925-35. doi: 10.1158/0008-5472.CAN-09-2715. Epub 2010 Jan 26. Cancer Res. 2010. PMID: 20103649 Free PMC article.

2

ATM activation and signaling under hypoxic conditions.

Bencokova Z, Kaufmann MR, Pires IM, Lecane PS, Giaccia AJ, Hammond EM. Bencokova Z, et al. Among authors: pires im. Mol Cell Biol. 2009 Jan;29(2):526-37. doi: 10.1128/MCB.01301-08. Epub 2008 Nov 3. Mol Cell Biol. 2009. PMID: 18981219 Free PMC article.

3

Exposure to acute hypoxia induces a transient DNA damage response which includes Chk1 and TLK1.

Pires IM, Bencokova Z, McGurk C, Hammond EM. Pires IM, et al. Cell Cycle. 2010 Jul 1;9(13):2502-7. doi: 10.4161/cc.9.13.12059. Cell Cycle. 2010. PMID: 20581459 Free PMC article.

4

Contextual synthetic lethality of cancer cell kill based on the tumor microenvironment.

Chan N, Pires IM, Bencokova Z, Coackley C, Luoto KR, Bhogal N, Lakshman M, Gottipati P, Oliver FJ, Helleday T, Hammond EM, Bristow RG. Chan N, et al. Among authors: pires im. Cancer Res. 2010 Oct 15;70(20):8045-54. doi: 10.1158/0008-5472.CAN-10-2352. Epub 2010 Oct 5. Cancer Res. 2010. PMID: 20924112 Free PMC article.

5

Hypoxia-driven cell motility reflects the interplay between JMY and HIF-1α.

Coutts AS, Pires IM, Weston L, Buffa FM, Milani M, Li JL, Harris AL, Hammond EM, La Thangue NB. Coutts AS, et al. Among authors: pires im. Oncogene. 2011 Dec 1;30(48):4835-42. doi: 10.1038/onc.2011.188. Epub 2011 May 30. Oncogene. 2011. PMID: 21625218

6

Targeting radiation-resistant hypoxic tumour cells through ATR inhibition.

Pires IM, Olcina MM, Anbalagan S, Pollard JR, Reaper PM, Charlton PA, McKenna WG, Hammond EM. Pires IM, et al. Br J Cancer. 2012 Jul 10;107(2):291-9. doi: 10.1038/bjc.2012.265. Epub 2012 Jun 19. Br J Cancer. 2012. PMID: 22713662 Free PMC article.

7

CH-01 is a hypoxia-activated prodrug that sensitizes cells to hypoxia/reoxygenation through inhibition of Chk1 and Aurora A.

Cazares-Körner C, Pires IM, Swallow ID, Grayer SC, O'Connor LJ, Olcina MM, Christlieb M, Conway SJ, Hammond EM. Cazares-Körner C, et al. Among authors: pires im. ACS Chem Biol. 2013 Jul 19;8(7):1451-9. doi: 10.1021/cb4001537. Epub 2013 May 10. ACS Chem Biol. 2013. PMID: 23597309 Free PMC article.

8

Replication stress and chromatin context link ATM activation to a role in DNA replication.

Olcina MM, Foskolou IP, Anbalagan S, Senra JM, Pires IM, Jiang Y, Ryan AJ, Hammond EM. Olcina MM, et al. Among authors: pires im. Mol Cell. 2013 Dec 12;52(5):758-66. doi: 10.1016/j.molcel.2013.10.019. Epub 2013 Nov 21. Mol Cell. 2013. PMID: 24268576 Free PMC article.

9

HIF-1α-independent hypoxia-induced rapid PTK6 stabilization is associated with increased motility and invasion.

Pires IM, Blokland NJ, Broos AW, Poujade FA, Senra JM, Eccles SA, Span PN, Harvey AJ, Hammond EM. Pires IM, et al. Cancer Biol Ther. 2014 Oct;15(10):1350-7. doi: 10.4161/cbt.29822. Epub 2014 Jul 14. Cancer Biol Ther. 2014. PMID: 25019382 Free PMC article.

10

Regulation of autophagy by ATF4 in response to severe hypoxia.

Rzymski T, Milani M, Pike L, Buffa F, Mellor HR, Winchester L, Pires I, Hammond E, Ragoussis I, Harris AL. Rzymski T, et al. Oncogene. 2010 Aug 5;29(31):4424-35. doi: 10.1038/onc.2010.191. Epub 2010 May 31. Oncogene. 2010. PMID: 20514020

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