Harden TK - Search Results

1

Polyamidoamine (PAMAM) dendrimer conjugates of "clickable" agonists of the A3 adenosine receptor and coactivation of the P2Y14 receptor by a tethered nucleotide.

Tosh DK, Yoo LS, Chinn M, Hong K, Kilbey SM 2nd, Barrett MO, Fricks IP, Harden TK, Gao ZG, Jacobson KA. Tosh DK, et al. Among authors: harden tk. Bioconjug Chem. 2010 Feb 17;21(2):372-84. doi: 10.1021/bc900473v. Bioconjug Chem. 2010. PMID: 20121074 Free PMC article.

2

Molecular modeling of the human P2Y2 receptor and design of a selective agonist, 2'-amino-2'-deoxy-2-thiouridine 5'-triphosphate.

Ivanov AA, Ko H, Cosyn L, Maddileti S, Besada P, Fricks I, Costanzi S, Harden TK, Calenbergh SV, Jacobson KA. Ivanov AA, et al. Among authors: harden tk. J Med Chem. 2007 Mar 22;50(6):1166-76. doi: 10.1021/jm060903o. Epub 2007 Feb 16. J Med Chem. 2007. PMID: 17302398 Free PMC article.

3

Structure-activity relationship of uridine 5'-diphosphoglucose analogues as agonists of the human P2Y14 receptor.

Ko H, Fricks I, Ivanov AA, Harden TK, Jacobson KA. Ko H, et al. Among authors: harden tk. J Med Chem. 2007 May 3;50(9):2030-9. doi: 10.1021/jm061222w. Epub 2007 Apr 4. J Med Chem. 2007. PMID: 17407275 Free PMC article.

4

Molecular recognition in the P2Y(14) receptor: Probing the structurally permissive terminal sugar moiety of uridine-5'-diphosphoglucose.

Ko H, Das A, Carter RL, Fricks IP, Zhou Y, Ivanov AA, Melman A, Joshi BV, Kovác P, Hajduch J, Kirk KL, Harden TK, Jacobson KA. Ko H, et al. Among authors: harden tk. Bioorg Med Chem. 2009 Jul 15;17(14):5298-311. doi: 10.1016/j.bmc.2009.05.024. Epub 2009 May 15. Bioorg Med Chem. 2009. PMID: 19502066 Free PMC article.

5

Enhanced potency of nucleotide-dendrimer conjugates as agonists of the P2Y14 receptor: multivalent effect in G protein-coupled receptor recognition.

Das A, Zhou Y, Ivanov AA, Carter RL, Harden TK, Jacobson KA. Das A, et al. Among authors: harden tk. Bioconjug Chem. 2009 Aug 19;20(8):1650-9. doi: 10.1021/bc900206g. Epub 2009 Jul 2. Bioconjug Chem. 2009. PMID: 19572637 Free PMC article.

6

Human P2Y(14) receptor agonists: truncation of the hexose moiety of uridine-5'-diphosphoglucose and its replacement with alkyl and aryl groups.

Das A, Ko H, Burianek LE, Barrett MO, Harden TK, Jacobson KA. Das A, et al. Among authors: harden tk. J Med Chem. 2010 Jan 14;53(1):471-80. doi: 10.1021/jm901432g. J Med Chem. 2010. PMID: 19902968 Free PMC article.

7

Pyrimidine ribonucleotides with enhanced selectivity as P2Y(6) receptor agonists: novel 4-alkyloxyimino, (S)-methanocarba, and 5'-triphosphate gamma-ester modifications.

Maruoka H, Barrett MO, Ko H, Tosh DK, Melman A, Burianek LE, Balasubramanian R, Berk B, Costanzi S, Harden TK, Jacobson KA. Maruoka H, et al. Among authors: harden tk. J Med Chem. 2010 Jun 10;53(11):4488-501. doi: 10.1021/jm100287t. J Med Chem. 2010. PMID: 20446735 Free PMC article.

8

Functionalized congeners of P2Y1 receptor antagonists: 2-alkynyl (N)-methanocarba 2'-deoxyadenosine 3',5'-bisphosphate analogues and conjugation to a polyamidoamine (PAMAM) dendrimer carrier.

de Castro S, Maruoka H, Hong K, Kilbey SM 2nd, Costanzi S, Hechler B, Brown GG Jr, Gachet C, Harden TK, Jacobson KA. de Castro S, et al. Among authors: harden tk. Bioconjug Chem. 2010 Jul 21;21(7):1190-205. doi: 10.1021/bc900569u. Bioconjug Chem. 2010. PMID: 20565071 Free PMC article.

9

Pyrimidine nucleotides with 4-alkyloxyimino and terminal tetraphosphate δ-ester modifications as selective agonists of the P2Y(4) receptor.

Maruoka H, Jayasekara MP, Barrett MO, Franklin DA, de Castro S, Kim N, Costanzi S, Harden TK, Jacobson KA. Maruoka H, et al. Among authors: harden tk. J Med Chem. 2011 Jun 23;54(12):4018-33. doi: 10.1021/jm101591j. Epub 2011 May 20. J Med Chem. 2011. PMID: 21528910 Free PMC article.

10

4-Alkyloxyimino derivatives of uridine-5'-triphosphate: distal modification of potent agonists as a strategy for molecular probes of P2Y2, P2Y4, and P2Y6 receptors.

Jayasekara PS, Barrett MO, Ball CB, Brown KA, Hammes E, Balasubramanian R, Harden TK, Jacobson KA. Jayasekara PS, et al. Among authors: harden tk. J Med Chem. 2014 May 8;57(9):3874-83. doi: 10.1021/jm500367e. Epub 2014 Apr 18. J Med Chem. 2014. PMID: 24712832 Free PMC article.

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