White HS - Search Results

1

Engineering galanin analogues that discriminate between GalR1 and GalR2 receptor subtypes and exhibit anticonvulsant activity following systemic delivery.

Robertson CR, Scholl EA, Pruess TH, Green BR, White HS, Bulaj G. Robertson CR, et al. Among authors: white hs. J Med Chem. 2010 Feb 25;53(4):1871-5. doi: 10.1021/jm9018349. J Med Chem. 2010. PMID: 20121116 Free PMC article.

2

Design, synthesis, and characterization of high-affinity, systemically-active galanin analogues with potent anticonvulsant activities.

Bulaj G, Green BR, Lee HK, Robertson CR, White K, Zhang L, Sochanska M, Flynn SP, Scholl EA, Pruess TH, Smith MD, White HS. Bulaj G, et al. Among authors: white hs, white k. J Med Chem. 2008 Dec 25;51(24):8038-47. doi: 10.1021/jm801088x. J Med Chem. 2008. PMID: 19053761

3

Glycosylated neurotensin analogues exhibit sub-picomolar anticonvulsant potency in a pharmacoresistant model of epilepsy.

Lee HK, Zhang L, Smith MD, White HS, Bulaj G. Lee HK, et al. Among authors: white hs. ChemMedChem. 2009 Mar;4(3):400-5. doi: 10.1002/cmdc.200800421. ChemMedChem. 2009. PMID: 19173215 Free PMC article.

4

Structural requirements for a lipoamino acid in modulating the anticonvulsant activities of systemically active galanin analogues.

Zhang L, Robertson CR, Green BR, Pruess TH, White HS, Bulaj G. Zhang L, et al. Among authors: white hs. J Med Chem. 2009 Mar 12;52(5):1310-6. doi: 10.1021/jm801397w. J Med Chem. 2009. PMID: 19199479 Free PMC article.

5

Synthesis and applications of polyamine amino acid residues: improving the bioactivity of an analgesic neuropeptide, neurotensin.

Zhang L, Lee HK, Pruess TH, White HS, Bulaj G. Zhang L, et al. Among authors: white hs. J Med Chem. 2009 Mar 26;52(6):1514-7. doi: 10.1021/jm801481y. J Med Chem. 2009. PMID: 19236044 Free PMC article.

6

Developing novel antiepileptic drugs: characterization of NAX 5055, a systemically-active galanin analog, in epilepsy models.

White HS, Scholl EA, Klein BD, Flynn SP, Pruess TH, Green BR, Zhang L, Bulaj G. White HS, et al. Neurotherapeutics. 2009 Apr;6(2):372-80. doi: 10.1016/j.nurt.2009.01.001. Neurotherapeutics. 2009. PMID: 19332332 Free PMC article.

7

Introduction of lipidization-cationization motifs affords systemically bioavailable neuropeptide Y and neurotensin analogs with anticonvulsant activities.

Green BR, White KL, McDougle DR, Zhang L, Klein B, Scholl EA, Pruess TH, White HS, Bulaj G. Green BR, et al. Among authors: white hs, white kl. J Pept Sci. 2010 Sep;16(9):486-95. doi: 10.1002/psc.1266. J Pept Sci. 2010. PMID: 20645434

8

Anticonvulsant neuropeptides as drug leads for neurological diseases.

Robertson CR, Flynn SP, White HS, Bulaj G. Robertson CR, et al. Among authors: white hs. Nat Prod Rep. 2011 Apr;28(4):741-62. doi: 10.1039/c0np00048e. Epub 2011 Feb 21. Nat Prod Rep. 2011. PMID: 21340067 Review.

9

Generating orally active galanin analogues with analgesic activities.

Robertson CR, Pruess TH, Grussendorf E, White HS, Bulaj G. Robertson CR, et al. Among authors: white hs. ChemMedChem. 2012 May;7(5):903-9. doi: 10.1002/cmdc.201100574. Epub 2012 Feb 28. ChemMedChem. 2012. PMID: 22374865 Free PMC article.

10

Incorporation of monodisperse oligoethyleneglycol amino acids into anticonvulsant analogues of galanin and neuropeptide y provides peripherally acting analgesics.

Zhang L, Klein BD, Metcalf CS, Smith MD, McDougle DR, Lee HK, White HS, Bulaj G. Zhang L, et al. Among authors: white hs. Mol Pharm. 2013 Feb 4;10(2):574-85. doi: 10.1021/mp300236v. Epub 2013 Jan 15. Mol Pharm. 2013. PMID: 23259957

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