Zheng M - Search Results

1

2,3-Diamino acid modifying 3S-tetrahydroisoquinoline-3-carboxylic acids: leading to a class of novel agents with highly unfolded conformation, selective in vitro anti-platelet aggregation and potent in vivo anti-thrombotic activity.

Zhang X, Wang W, Cheng S, Zhao M, Zheng M, Chang HW, Wu J, Peng S. Zhang X, et al. Among authors: zheng m. Bioorg Med Chem. 2010 Feb 15;18(4):1536-54. doi: 10.1016/j.bmc.2010.01.009. Epub 2010 Jan 13. Bioorg Med Chem. 2010. PMID: 20122838

2

(3S)-N-(L-Aminoacyl)-1,2,3,4-tetrahydroisoquinolines, a class of novel antithrombotic agents: synthesis, bioassay, 3D QSAR, and ADME analysis.

Zheng M, Zhang X, Zhao M, Chang HW, Wang W, Wang Y, Peng S. Zheng M, et al. Bioorg Med Chem. 2008 Nov 1;16(21):9574-87. doi: 10.1016/j.bmc.2008.09.019. Epub 2008 Sep 12. Bioorg Med Chem. 2008. PMID: 18835178

3

A class of novel N-(3S-1,2,3,4-tetrahydroisoquinoline-3-carbonyl)-L-amino acid derivatives: their synthesis, anti-thrombotic activity evaluation, and 3D QSAR analysis.

Cheng S, Zhang X, Wang W, Zhao M, Zheng M, Chang HW, Wu J, Peng S. Cheng S, et al. Among authors: zheng m. Eur J Med Chem. 2009 Dec;44(12):4904-19. doi: 10.1016/j.ejmech.2009.08.002. Epub 2009 Aug 6. Eur J Med Chem. 2009. PMID: 19729231

4

A class of novel Schiff's bases: Synthesis, therapeutic action for chronic pain, anti-inflammation and 3D QSAR analysis.

Zhou Y, Zhao M, Wu Y, Li C, Wu J, Zheng M, Peng L, Peng S. Zhou Y, et al. Among authors: zheng m. Bioorg Med Chem. 2010 Mar 15;18(6):2165-2172. doi: 10.1016/j.bmc.2010.01.075. Epub 2010 Feb 6. Bioorg Med Chem. 2010. PMID: 20176491

5

A class of 3S-2-aminoacyltetrahydro-beta-carboline-3-carboxylic acids: their facile synthesis, inhibition for platelet activation, and high in vivo anti-thrombotic potency.

Liu J, Jiang X, Zhao M, Zhang X, Zheng M, Peng L, Peng S. Liu J, et al. Among authors: zheng m. J Med Chem. 2010 Apr 22;53(8):3106-16. doi: 10.1021/jm901816j. J Med Chem. 2010. PMID: 20329729

6

Lead detoxification activities and ADMET hepatotoxicities of a class of novel 5-(1-carbonyl-L-amino-acid)-2,2-dimethyl-[1,3]dithiolane-4-carboxylic acids.

Xu Y, Wang Y, Zhao M, Hou B, Peng L, Zheng M, Wu J, Peng S. Xu Y, et al. Among authors: zheng m. Bioorg Med Chem Lett. 2011 Mar 15;21(6):1754-7. doi: 10.1016/j.bmcl.2011.01.070. Epub 2011 Jan 22. Bioorg Med Chem Lett. 2011. PMID: 21316230

7

A class of novel N-isoquinoline-3-carbonyl-L-amino acid benzylesters: synthesis, anti-tumor evaluation and 3D QSAR analysis.

Zheng M, Yang Y, Zhao M, Zhang X, Wu J, Chen G, Peng L, Wang Y, Peng S. Zheng M, et al. Eur J Med Chem. 2011 May;46(5):1672-81. doi: 10.1016/j.ejmech.2011.02.017. Epub 2011 Feb 22. Eur J Med Chem. 2011. PMID: 21414693

8

A class of oral N-[(1S,3S)-1-methyl-1,2,3,4-tetrahydro-β-carboline-3-carbonyl]- N'-(amino-acid-acyl)hydrazine: discovery, synthesis, in vitro anti-platelet aggregation/in vivo anti-thrombotic evaluation and 3D QSAR analysis.

Yao K, Zhao M, Zhang X, Wang Y, Li L, Zheng M, Peng S. Yao K, et al. Among authors: zheng m. Eur J Med Chem. 2011 Aug;46(8):3237-49. doi: 10.1016/j.ejmech.2011.04.037. Epub 2011 Apr 29. Eur J Med Chem. 2011. PMID: 21571404

9

A class of Trp-Trp-AA-OBzl: Synthesis, in vitro anti-proliferation/in vivo anti-tumor evaluation, intercalation-mechanism investigation and 3D QSAR analysis.

Zhang X, Yang Y, Zhao M, Liu L, Zheng M, Wang Y, Wu J, Peng S. Zhang X, et al. Among authors: zheng m. Eur J Med Chem. 2011 Aug;46(8):3410-9. doi: 10.1016/j.ejmech.2011.05.004. Epub 2011 May 12. Eur J Med Chem. 2011. PMID: 21620529

10

A class of novel N-(1-methyl-β-carboline-3-carbonyl)-N'-(aminoacid-acyl)-hydrazines: aromatization leaded design, synthesis, in vitro anti-platelet aggregation/in vivo anti-thrombotic evaluation and 3D QSAR analysis.

Li C, Zhang X, Zhao M, Wang Y, Wu J, Liu J, Zheng M, Peng S. Li C, et al. Among authors: zheng m. Eur J Med Chem. 2011 Nov;46(11):5598-608. doi: 10.1016/j.ejmech.2011.09.027. Epub 2011 Sep 24. Eur J Med Chem. 2011. PMID: 21983333

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