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Priming immunization with DNA augments immunogenicity of recombinant adenoviral vectors for both HIV-1 specific antibody and T-cell responses.
Koup RA, Roederer M, Lamoreaux L, Fischer J, Novik L, Nason MC, Larkin BD, Enama ME, Ledgerwood JE, Bailer RT, Mascola JR, Nabel GJ, Graham BS; VRC 009 Study Team; VRC 010 Study Team. Koup RA, et al. PLoS One. 2010 Feb 2;5(2):e9015. doi: 10.1371/journal.pone.0009015. PLoS One. 2010. PMID: 20126394 Free PMC article. Clinical Trial.
Evidence for increased T cell turnover and decreased thymic output in HIV infection.
Douek DC, Betts MR, Hill BJ, Little SJ, Lempicki R, Metcalf JA, Casazza J, Yoder C, Adelsberger JW, Stevens RA, Baseler MW, Keiser P, Richman DD, Davey RT, Koup RA. Douek DC, et al. Among authors: koup ra. J Immunol. 2001 Dec 1;167(11):6663-8. doi: 10.4049/jimmunol.167.11.6663. J Immunol. 2001. PMID: 11714838
HIV preferentially infects HIV-specific CD4+ T cells.
Douek DC, Brenchley JM, Betts MR, Ambrozak DR, Hill BJ, Okamoto Y, Casazza JP, Kuruppu J, Kunstman K, Wolinsky S, Grossman Z, Dybul M, Oxenius A, Price DA, Connors M, Koup RA. Douek DC, et al. Among authors: koup ra. Nature. 2002 May 2;417(6884):95-8. doi: 10.1038/417095a. Nature. 2002. PMID: 11986671
444 results