Marjamäki A - Search Results

1

A small-molecule inhibitor of integrin alpha2 beta1 introduces a new strategy for antithrombotic therapy.

Nissinen L, Pentikäinen OT, Jouppila A, Käpylä J, Ojala M, Nieminen J, Lipsanen A, Lappalainen H, Eckes B, Johnson MS, Lassila R, Marjamäki A, Heino J. Nissinen L, et al. Among authors: marjamaki a. Thromb Haemost. 2010 Feb;103(2):387-97. doi: 10.1160/TH09-06-0358. Epub 2009 Dec 1. Thromb Haemost. 2010. PMID: 20126829

2

Small molecule designed to target metal binding site in the alpha2I domain inhibits integrin function.

Käpylä J, Pentikäinen OT, Nyrönen T, Nissinen L, Lassander S, Jokinen J, Lahti M, Marjamäki A, Johnson MS, Heino J. Käpylä J, et al. Among authors: marjamaki a. J Med Chem. 2007 May 31;50(11):2742-6. doi: 10.1021/jm070063t. Epub 2007 Apr 21. J Med Chem. 2007. PMID: 17447751

3

Novel α2β1 integrin inhibitors reveal that integrin binding to collagen under shear stress conditions does not require receptor preactivation.

Nissinen L, Koivunen J, Käpylä J, Salmela M, Nieminen J, Jokinen J, Sipilä K, Pihlavisto M, Pentikäinen OT, Marjamäki A, Heino J. Nissinen L, et al. Among authors: marjamaki a. J Biol Chem. 2012 Dec 28;287(53):44694-702. doi: 10.1074/jbc.M111.309450. Epub 2012 Nov 6. J Biol Chem. 2012. PMID: 23132859 Free PMC article.

4

Platelet response to a small molecule inhibitor of α2β1 integrin is associated with ITGA2 C807T dimorphism.

Nissinen L, Rappu P, Ollikka P, Nieminen J, Marjamäki A, Heino J. Nissinen L, et al. Among authors: marjamaki a. Platelets. 2016 Jun;27(4):378-80. doi: 10.3109/09537104.2015.1095877. Epub 2015 Nov 10. Platelets. 2016. PMID: 26556301 Free article.

5

Fluorescent small molecule probe to modulate and explore α2β1 integrin function.

Koivunen JT, Nissinen L, Käpylä J, Jokinen J, Pihlavisto M, Marjamäki A, Heino J, Huuskonen J, Pentikäinen OT. Koivunen JT, et al. Among authors: marjamaki a. J Am Chem Soc. 2011 Sep 21;133(37):14558-61. doi: 10.1021/ja206086c. Epub 2011 Aug 30. J Am Chem Soc. 2011. PMID: 21863823

6

Sulfonamide inhibitors of α2β1 integrin reveal the essential role of collagen receptors in in vivo models of inflammation.

Nissinen L, Ojala M, Langen B, Dost R, Pihlavisto M, Käpylä J, Marjamäki A, Heino J. Nissinen L, et al. Among authors: marjamaki a. Pharmacol Res Perspect. 2015 Jun;3(3):e00146. doi: 10.1002/prp2.146. Epub 2015 May 15. Pharmacol Res Perspect. 2015. PMID: 26171226 Free PMC article.

7

O-sulfated bacterial polysaccharides with low anticoagulant activity inhibit metastasis.

Borgenström M, Wärri A, Hiilesvuo K, Käkönen R, Käkönen S, Nissinen L, Pihlavisto M, Marjamäki A, Vlodavsky I, Naggi A, Torri G, Casu B, Veromaa T, Salmivirta M, Elenius K. Borgenström M, et al. Among authors: marjamaki a. Semin Thromb Hemost. 2007 Jul;33(5):547-56. doi: 10.1055/s-2007-982087. Semin Thromb Hemost. 2007. PMID: 17629853

8

Heparin-like polysaccharides reduce osteolytic bone destruction and tumor growth in a mouse model of breast cancer bone metastasis.

Pollari S, Käkönen RS, Mohammad KS, Rissanen JP, Halleen JM, Wärri A, Nissinen L, Pihlavisto M, Marjamäki A, Perälä M, Guise TA, Kallioniemi O, Käkönen SM. Pollari S, et al. Among authors: marjamaki a. Mol Cancer Res. 2012 May;10(5):597-604. doi: 10.1158/1541-7786.MCR-11-0482. Epub 2012 Apr 20. Mol Cancer Res. 2012. PMID: 22522458

9

Chloroethylclonidine and 2-aminoethyl methanethiosulfonate recognize two different conformations of the human alpha(2A)-adrenergic receptor.

Marjamäki A, Frang H, Pihlavisto M, Hoffrén AM, Salminen T, Johnson MS, Kallio J, Javitch JA, Scheinin M. Marjamäki A, et al. J Biol Chem. 1999 Jul 30;274(31):21867-72. doi: 10.1074/jbc.274.31.21867. J Biol Chem. 1999. PMID: 10419505 Free article.

10

Conserved structural, pharmacological and functional properties among the three human and five zebrafish alpha 2-adrenoceptors.

Ruuskanen JO, Laurila J, Xhaard H, Rantanen VV, Vuoriluoto K, Wurster S, Marjamäki A, Vainio M, Johnson MS, Scheinin M. Ruuskanen JO, et al. Among authors: marjamaki a. Br J Pharmacol. 2005 Jan;144(2):165-77. doi: 10.1038/sj.bjp.0706057. Br J Pharmacol. 2005. PMID: 15655522 Free PMC article.

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