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Structures of a minimal human CFTR first nucleotide-binding domain as a monomer, head-to-tail homodimer, and pathogenic mutant.
Atwell S, Brouillette CG, Conners K, Emtage S, Gheyi T, Guggino WB, Hendle J, Hunt JF, Lewis HA, Lu F, Protasevich II, Rodgers LA, Romero R, Wasserman SR, Weber PC, Wetmore D, Zhang FF, Zhao X. Atwell S, et al. Among authors: guggino wb. Protein Eng Des Sel. 2010 May;23(5):375-84. doi: 10.1093/protein/gzq004. Epub 2010 Feb 11. Protein Eng Des Sel. 2010. PMID: 20150177
Impact of the deltaF508 mutation in first nucleotide-binding domain of human cystic fibrosis transmembrane conductance regulator on domain folding and structure.
Lewis HA, Zhao X, Wang C, Sauder JM, Rooney I, Noland BW, Lorimer D, Kearins MC, Conners K, Condon B, Maloney PC, Guggino WB, Hunt JF, Emtage S. Lewis HA, et al. Among authors: guggino wb. J Biol Chem. 2005 Jan 14;280(2):1346-53. doi: 10.1074/jbc.M410968200. Epub 2004 Nov 3. J Biol Chem. 2005. PMID: 15528182 Free article.
Structure of nucleotide-binding domain 1 of the cystic fibrosis transmembrane conductance regulator.
Lewis HA, Buchanan SG, Burley SK, Conners K, Dickey M, Dorwart M, Fowler R, Gao X, Guggino WB, Hendrickson WA, Hunt JF, Kearins MC, Lorimer D, Maloney PC, Post KW, Rajashankar KR, Rutter ME, Sauder JM, Shriver S, Thibodeau PH, Thomas PJ, Zhang M, Zhao X, Emtage S. Lewis HA, et al. Among authors: guggino wb. EMBO J. 2004 Jan 28;23(2):282-93. doi: 10.1038/sj.emboj.7600040. Epub 2003 Dec 18. EMBO J. 2004. PMID: 14685259 Free PMC article.
CFTR: domains, structure, and function.
Devidas S, Guggino WB. Devidas S, et al. Among authors: guggino wb. J Bioenerg Biomembr. 1997 Oct;29(5):443-51. doi: 10.1023/a:1022430906284. J Bioenerg Biomembr. 1997. PMID: 9511929 Review.
CFTR Folding Consortium: methods available for studies of CFTR folding and correction.
Peters KW, Okiyoneda T, Balch WE, Braakman I, Brodsky JL, Guggino WB, Penland CM, Pollard HB, Sorscher EJ, Skach WR, Thomas PJ, Lukacs GL, Frizzell RA. Peters KW, et al. Among authors: guggino wb. Methods Mol Biol. 2011;742:335-53. doi: 10.1007/978-1-61779-120-8_20. Methods Mol Biol. 2011. PMID: 21547742 Free PMC article.
Gout-causing Q141K mutation in ABCG2 leads to instability of the nucleotide-binding domain and can be corrected with small molecules.
Woodward OM, Tukaye DN, Cui J, Greenwell P, Constantoulakis LM, Parker BS, Rao A, Köttgen M, Maloney PC, Guggino WB. Woodward OM, et al. Among authors: guggino wb. Proc Natl Acad Sci U S A. 2013 Mar 26;110(13):5223-8. doi: 10.1073/pnas.1214530110. Epub 2013 Mar 14. Proc Natl Acad Sci U S A. 2013. PMID: 23493553 Free PMC article.
From CFTR biology toward combinatorial pharmacotherapy: expanded classification of cystic fibrosis mutations.
Veit G, Avramescu RG, Chiang AN, Houck SA, Cai Z, Peters KW, Hong JS, Pollard HB, Guggino WB, Balch WE, Skach WR, Cutting GR, Frizzell RA, Sheppard DN, Cyr DM, Sorscher EJ, Brodsky JL, Lukacs GL. Veit G, et al. Among authors: guggino wb. Mol Biol Cell. 2016 Feb 1;27(3):424-33. doi: 10.1091/mbc.E14-04-0935. Mol Biol Cell. 2016. PMID: 26823392 Free PMC article.
268 results