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Robust anti-arrhythmic efficacy of verapamil and flunarizine against dofetilide-induced TdP arrhythmias is based upon a shared and a different mode of action.
Oros A, Houtman MJ, Neco P, Gomez AM, Rajamani S, Oosterhoff P, Attevelt NJ, Beekman JD, van der Heyden MA, Ver Donck L, Belardinelli L, Richard S, Antoons G, Vos MA; CONTICA investigators. Oros A, et al. Among authors: beekman jd. Br J Pharmacol. 2010 Sep;161(1):162-75. doi: 10.1111/j.1476-5381.2010.00883.x. Br J Pharmacol. 2010. PMID: 20718748 Free PMC article.
Drug-induced torsade de pointes arrhythmias in the chronic AV block dog are perpetuated by focal activity.
Boulaksil M, Jungschleger JG, Antoons G, Houtman MJ, de Boer TP, Wilders R, Beekman JD, Maessen JG, van der Hulst FF, van der Heyden MA, van Veen TA, van Rijen HV, de Bakker JM, Vos MA. Boulaksil M, et al. Among authors: beekman jd. Circ Arrhythm Electrophysiol. 2011 Aug;4(4):566-76. doi: 10.1161/CIRCEP.110.958991. Epub 2011 May 27. Circ Arrhythm Electrophysiol. 2011. PMID: 21622813
40 results