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Acadesine inhibits tissue factor induction and thrombus formation by activating the phosphoinositide 3-kinase/Akt signaling pathway.
Zhang W, Wang J, Wang H, Tang R, Belcher JD, Viollet B, Geng JG, Zhang C, Wu C, Slungaard A, Zhu C, Huo Y. Zhang W, et al. Among authors: wang h, wang j. Arterioscler Thromb Vasc Biol. 2010 May;30(5):1000-6. doi: 10.1161/ATVBAHA.110.203141. Epub 2010 Feb 25. Arterioscler Thromb Vasc Biol. 2010. PMID: 20185792 Free PMC article.
Elevated prothrombin promotes venous, but not arterial, thrombosis in mice.
Aleman MM, Walton BL, Byrnes JR, Wang JG, Heisler MJ, Machlus KR, Cooley BC, Wolberg AS. Aleman MM, et al. Among authors: wang jg. Arterioscler Thromb Vasc Biol. 2013 Aug;33(8):1829-36. doi: 10.1161/ATVBAHA.113.301607. Epub 2013 May 30. Arterioscler Thromb Vasc Biol. 2013. PMID: 23723374 Free PMC article.
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