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Thymic selection of T-cell receptors as an extreme value problem.
Kosmrlj A, Chakraborty AK, Kardar M, Shakhnovich EI. Kosmrlj A, et al. Among authors: chakraborty ak. Phys Rev Lett. 2009 Aug 7;103(6):068103. doi: 10.1103/PhysRevLett.103.068103. Epub 2009 Aug 7. Phys Rev Lett. 2009. PMID: 19792616
Fast on-rates allow short dwell time ligands to activate T cells.
Govern CC, Paczosa MK, Chakraborty AK, Huseby ES. Govern CC, et al. Among authors: chakraborty ak. Proc Natl Acad Sci U S A. 2010 May 11;107(19):8724-9. doi: 10.1073/pnas.1000966107. Epub 2010 Apr 26. Proc Natl Acad Sci U S A. 2010. PMID: 20421471 Free PMC article.
CD4 and CD8 binding to MHC molecules primarily acts to enhance Lck delivery.
Artyomov MN, Lis M, Devadas S, Davis MM, Chakraborty AK. Artyomov MN, et al. Among authors: chakraborty ak. Proc Natl Acad Sci U S A. 2010 Sep 28;107(39):16916-21. doi: 10.1073/pnas.1010568107. Epub 2010 Sep 13. Proc Natl Acad Sci U S A. 2010. PMID: 20837541 Free PMC article.
398 results