Cirit M - Search Results

1

Stochastic model of integrin-mediated signaling and adhesion dynamics at the leading edges of migrating cells.

Cirit M, Krajcovic M, Choi CK, Welf ES, Horwitz AF, Haugh JM. Cirit M, et al. PLoS Comput Biol. 2010 Feb 26;6(2):e1000688. doi: 10.1371/journal.pcbi.1000688. PLoS Comput Biol. 2010. PMID: 20195494 Free PMC article.

2

PI3K-dependent cross-talk interactions converge with Ras as quantifiable inputs integrated by Erk.

Wang CC, Cirit M, Haugh JM. Wang CC, et al. Among authors: cirit m. Mol Syst Biol. 2009;5:246. doi: 10.1038/msb.2009.4. Epub 2009 Feb 17. Mol Syst Biol. 2009. PMID: 19225459 Free PMC article.

3

Systematic quantification of negative feedback mechanisms in the extracellular signal-regulated kinase (ERK) signaling network.

Cirit M, Wang CC, Haugh JM. Cirit M, et al. J Biol Chem. 2010 Nov 19;285(47):36736-44. doi: 10.1074/jbc.M110.148759. Epub 2010 Sep 16. J Biol Chem. 2010. PMID: 20847054 Free PMC article.

4

Data-driven modelling of receptor tyrosine kinase signalling networks quantifies receptor-specific potencies of PI3K- and Ras-dependent ERK activation.

Cirit M, Haugh JM. Cirit M, et al. Biochem J. 2012 Jan 1;441(1):77-85. doi: 10.1042/BJ20110833. Biochem J. 2012. PMID: 21943356 Free PMC article.

5

Quantitative models of signal transduction networks: How detailed should they be?

Cirit M, Haugh JM. Cirit M, et al. Commun Integr Biol. 2011 May;4(3):353-6. doi: 10.4161/cib.4.3.15149. Commun Integr Biol. 2011. PMID: 21980579 Free PMC article.

6

Data-driven modeling reconciles kinetics of ERK phosphorylation, localization, and activity states.

Ahmed S, Grant KG, Edwards LE, Rahman A, Cirit M, Goshe MB, Haugh JM. Ahmed S, et al. Among authors: cirit m. Mol Syst Biol. 2014 Jan 30;10(1):718. doi: 10.1002/msb.134708. Print 2014. Mol Syst Biol. 2014. PMID: 24489118 Free PMC article.

7

Allosteric modulation of Ras-GTP is linked to signal transduction through RAF kinase.

Buhrman G, Kumar VS, Cirit M, Haugh JM, Mattos C. Buhrman G, et al. Among authors: cirit m. J Biol Chem. 2011 Feb 4;286(5):3323-31. doi: 10.1074/jbc.M110.193854. Epub 2010 Nov 22. J Biol Chem. 2011. PMID: 21098031 Free PMC article.

8

Systemic perturbation of the ERK signaling pathway by the proteasome inhibitor, MG132.

Cirit M, Grant KG, Haugh JM. Cirit M, et al. PLoS One. 2012;7(11):e50975. doi: 10.1371/journal.pone.0050975. Epub 2012 Nov 30. PLoS One. 2012. PMID: 23226437 Free PMC article.

9

Quantitative Systems Pharmacology Approaches Applied to Microphysiological Systems (MPS): Data Interpretation and Multi-MPS Integration.

Yu J, Cilfone NA, Large EM, Sarkar U, Wishnok JS, Tannenbaum SR, Hughes DJ, Lauffenburger DA, Griffith LG, Stokes CL, Cirit M. Yu J, et al. Among authors: cirit m. CPT Pharmacometrics Syst Pharmacol. 2015 Oct;4(10):585-94. doi: 10.1002/psp4.12010. Epub 2015 Oct 5. CPT Pharmacometrics Syst Pharmacol. 2015. PMID: 26535159 Free PMC article.

10

Multi-functional scaling methodology for translational pharmacokinetic and pharmacodynamic applications using integrated microphysiological systems (MPS).

Maass C, Stokes CL, Griffith LG, Cirit M. Maass C, et al. Among authors: cirit m. Integr Biol (Camb). 2017 Apr 18;9(4):290-302. doi: 10.1039/c6ib00243a. Integr Biol (Camb). 2017. PMID: 28267162 Free PMC article.

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