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816 results

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Molecular pharmacology and antitumor activity of PHT-427, a novel Akt/phosphatidylinositide-dependent protein kinase 1 pleckstrin homology domain inhibitor.
Meuillet EJ, Zuohe S, Lemos R, Ihle N, Kingston J, Watkins R, Moses SA, Zhang S, Du-Cuny L, Herbst R, Jacoby JJ, Zhou LL, Ahad AM, Mash EA, Kirkpatrick DL, Powis G. Meuillet EJ, et al. Among authors: watkins r. Mol Cancer Ther. 2010 Mar;9(3):706-17. doi: 10.1158/1535-7163.MCT-09-0985. Epub 2010 Mar 2. Mol Cancer Ther. 2010. PMID: 20197390 Free PMC article.
Human PXR forms a tryptophan zipper-mediated homodimer.
Noble SM, Carnahan VE, Moore LB, Luntz T, Wang H, Ittoop OR, Stimmel JB, Davis-Searles PR, Watkins RE, Wisely GB, LeCluyse E, Tripathy A, McDonnell DP, Redinbo MR. Noble SM, et al. Among authors: watkins re. Biochemistry. 2006 Jul 18;45(28):8579-89. doi: 10.1021/bi0602821. Biochemistry. 2006. PMID: 16834332 Free PMC article.
Optimization of SARS-CoV-2 culture from clinical samples for clinical trial applications.
Wooding D, Buist K, Romero-Ramirez A, Savage H, Watkins R, Bengey D, Greenland-Bews C, Thompson CR, Kontogianni N, Body R, Hayward G, Byrne RL, Gould S; CONDOR Steering Group; Myerscough C, Atkinson B, Shaw V, Greenhalf B, Adams E, Cubas-Atienzar A, Khoo S, Fletcher T, Edwards T. Wooding D, et al. Among authors: watkins r. mSphere. 2024 Oct 16:e0030424. doi: 10.1128/msphere.00304-24. Online ahead of print. mSphere. 2024. PMID: 39412283 Free article.
Durable Immune Response and Long-term Efficacy of COVID-19 Vaccination in Children With Inflammatory Bowel Disease.
Kastl AJ, Brenner EJ, Weaver KN, Zhang X, Strople JA, Adler J, Dubinsky MC, Bousvaros A, Watkins R, Dai X, Chen W, Cross RK, Higgins PDR, Ungaro RC, Bewtra M, Bellaguarda EA, Farraye FA, Chun KY, Zikry M, Bastidas M, Firestine AM, Craig RG, Boccieri ME, Long MD, Kappelman MD. Kastl AJ, et al. Among authors: watkins r. Inflamm Bowel Dis. 2024 Oct 16:izae225. doi: 10.1093/ibd/izae225. Online ahead of print. Inflamm Bowel Dis. 2024. PMID: 39412147
YAP-TEAD inhibition is associated with upregulation of an androgen receptor mediated transcription program providing therapeutic escape.
Alva-Ruiz R, Watkins RD, Tomlinson JL, Yonkus JA, Abdelrahman AM, Conboy CB, Jessen E, Werneburg NW, Kuipers H, Sample JW, Gores GJ, Ilyas SI, Truty MJ, Smoot RL. Alva-Ruiz R, et al. Among authors: watkins rd. FEBS Open Bio. 2024 Nov;14(11):1873-1887. doi: 10.1002/2211-5463.13901. Epub 2024 Sep 19. FEBS Open Bio. 2024. PMID: 39300603 Free PMC article.
816 results