Dumotier B - Search Results

1

Conformational refinement of hydroxamate-based histone deacetylase inhibitors and exploration of 3-piperidin-3-ylindole analogues of dacinostat (LAQ824).

Cho YS, Whitehead L, Li J, Chen CH, Jiang L, Vögtle M, Francotte E, Richert P, Wagner T, Traebert M, Lu Q, Cao X, Dumotier B, Fejzo J, Rajan S, Wang P, Yan-Neale Y, Shao W, Atadja P, Shultz M. Cho YS, et al. Among authors: dumotier b. J Med Chem. 2010 Apr 8;53(7):2952-63. doi: 10.1021/jm100007m. J Med Chem. 2010. PMID: 20205394

2

Antimalarial drugs: QT prolongation and cardiac arrhythmias.

Traebert M, Dumotier B. Traebert M, et al. Among authors: dumotier b. Expert Opin Drug Saf. 2005 May;4(3):421-31. doi: 10.1517/14740338.4.3.421. Expert Opin Drug Saf. 2005. PMID: 15934850 Review.

3

Relevance of in vitro SCREENIT results for drug-induced QT interval prolongation in vivo: a database review and analysis.

Dumotier BM, Deurinck M, Yang Y, Traebert M, Suter W. Dumotier BM, et al. Pharmacol Ther. 2008 Aug;119(2):152-9. doi: 10.1016/j.pharmthera.2008.03.001. Epub 2008 Mar 26. Pharmacol Ther. 2008. PMID: 18462801

4

Selective block of IKs plays a significant role in MAP triangulation induced by IKr block in isolated rabbit heart.

Guérard NC, Traebert M, Suter W, Dumotier BM. Guérard NC, et al. Among authors: dumotier bm. J Pharmacol Toxicol Methods. 2008 Jul-Aug;58(1):32-40. doi: 10.1016/j.vascn.2008.05.129. Epub 2008 Jun 8. J Pharmacol Toxicol Methods. 2008. PMID: 18582585

5

Cardiotoxic Potential of Hydroxychloroquine, Chloroquine and Azithromycin in Adult Human Primary Cardiomyocytes.

Jordaan P, Dumotier B, Traebert M, Miller PE, Ghetti A, Urban L, Abi-Gerges N. Jordaan P, et al. Among authors: dumotier b. Toxicol Sci. 2021 Apr 12;180(2):356-368. doi: 10.1093/toxsci/kfaa194. Toxicol Sci. 2021. PMID: 33483756 Free PMC article.

6

Inhibition of hERG K+ currents by antimalarial drugs in stably transfected HEK293 cells.

Traebert M, Dumotier B, Meister L, Hoffmann P, Dominguez-Estevez M, Suter W. Traebert M, et al. Among authors: dumotier b. Eur J Pharmacol. 2004 Jan 19;484(1):41-8. doi: 10.1016/j.ejphar.2003.11.003. Eur J Pharmacol. 2004. PMID: 14729380

7

Oscillations of cardiac wave length and proarrhythmia.

Hondeghem LM, Dumotier B, Traebert M. Hondeghem LM, et al. Among authors: dumotier b. Naunyn Schmiedebergs Arch Pharmacol. 2010 Oct;382(4):367-76. doi: 10.1007/s00210-010-0549-y. Epub 2010 Aug 29. Naunyn Schmiedebergs Arch Pharmacol. 2010. PMID: 20803191

8

Blinded Contractility Analysis in hiPSC-Cardiomyocytes in Engineered Heart Tissue Format: Comparison With Human Atrial Trabeculae.

Mannhardt I, Eder A, Dumotier B, Prondzynski M, Krämer E, Traebert M, Söhren KD, Flenner F, Stathopoulou K, Lemoine MD, Carrier L, Christ T, Eschenhagen T, Hansen A. Mannhardt I, et al. Among authors: dumotier b. Toxicol Sci. 2017 Jul 1;158(1):164-175. doi: 10.1093/toxsci/kfx081. Toxicol Sci. 2017. PMID: 28453742 Free PMC article.

9

Preclinical cardiac safety assessment of pharmaceutical compounds using an integrated systems-based computer model of the heart.

Bottino D, Penland RC, stamps A, Traebert M, Dumotier B, Georgiva A, Helmlinger G, Lett GS. Bottino D, et al. Among authors: dumotier b. Prog Biophys Mol Biol. 2006 Jan-Apr;90(1-3):414-43. doi: 10.1016/j.pbiomolbio.2005.06.006. Prog Biophys Mol Biol. 2006. PMID: 16321428

10

Analysis of unipolar electrograms in rabbit heart demonstrated the key role of ventricular apicobasal dispersion in arrhythmogenicity.

Guérard N, Jordaan P, Dumotier B. Guérard N, et al. Among authors: dumotier b. Cardiovasc Toxicol. 2014 Dec;14(4):316-28. doi: 10.1007/s12012-014-9254-2. Cardiovasc Toxicol. 2014. PMID: 24740433

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