Hatzelmann A - Search Results

1

A phosphodiesterase 4 inhibitor, roflumilast N-oxide, inhibits human lung fibroblast functions in vitro.

Sabatini F, Petecchia L, Boero S, Silvestri M, Klar J, Tenor H, Beume R, Hatzelmann A, Rossi GA. Sabatini F, et al. Among authors: hatzelmann a. Pulm Pharmacol Ther. 2010 Aug;23(4):283-91. doi: 10.1016/j.pupt.2010.02.004. Epub 2010 Mar 11. Pulm Pharmacol Ther. 2010. PMID: 20226872

2

The preclinical pharmacology of roflumilast--a selective, oral phosphodiesterase 4 inhibitor in development for chronic obstructive pulmonary disease.

Hatzelmann A, Morcillo EJ, Lungarella G, Adnot S, Sanjar S, Beume R, Schudt C, Tenor H. Hatzelmann A, et al. Pulm Pharmacol Ther. 2010 Aug;23(4):235-56. doi: 10.1016/j.pupt.2010.03.011. Epub 2010 Apr 7. Pulm Pharmacol Ther. 2010. PMID: 20381629 Review.

3

Inhibition of TGF-beta induced lung fibroblast to myofibroblast conversion by phosphodiesterase inhibiting drugs and activators of soluble guanylyl cyclase.

Dunkern TR, Feurstein D, Rossi GA, Sabatini F, Hatzelmann A. Dunkern TR, et al. Among authors: hatzelmann a. Eur J Pharmacol. 2007 Oct 15;572(1):12-22. doi: 10.1016/j.ejphar.2007.06.036. Epub 2007 Jun 29. Eur J Pharmacol. 2007. PMID: 17659276

4

Effects of roflumilast, a phosphodiesterase-4 inhibitor, on hypoxia- and monocrotaline-induced pulmonary hypertension in rats.

Izikki M, Raffestin B, Klar J, Hatzelmann A, Marx D, Tenor H, Zadigue P, Adnot S, Eddahibi S. Izikki M, et al. Among authors: hatzelmann a. J Pharmacol Exp Ther. 2009 Jul;330(1):54-62. doi: 10.1124/jpet.108.148742. Epub 2009 Apr 22. J Pharmacol Exp Ther. 2009. PMID: 19386793

5

In vivo efficacy in airway disease models of roflumilast, a novel orally active PDE4 inhibitor.

Bundschuh DS, Eltze M, Barsig J, Wollin L, Hatzelmann A, Beume R. Bundschuh DS, et al. Among authors: hatzelmann a. J Pharmacol Exp Ther. 2001 Apr;297(1):280-90. J Pharmacol Exp Ther. 2001. PMID: 11259555

6

Roflumilast inhibits leukocyte-endothelial cell interactions, expression of adhesion molecules and microvascular permeability.

Sanz MJ, Cortijo J, Taha MA, Cerdá-Nicolás M, Schatton E, Burgbacher B, Klar J, Tenor H, Schudt C, Issekutz AC, Hatzelmann A, Morcillo EJ. Sanz MJ, et al. Among authors: hatzelmann a. Br J Pharmacol. 2007 Oct;152(4):481-92. doi: 10.1038/sj.bjp.0707428. Epub 2007 Aug 20. Br J Pharmacol. 2007. PMID: 17704822 Free PMC article.

7

Roflumilast, a phosphodiesterase 4 inhibitor, alleviates bleomycin-induced lung injury.

Cortijo J, Iranzo A, Milara X, Mata M, Cerdá-Nicolás M, Ruiz-Saurí A, Tenor H, Hatzelmann A, Morcillo EJ. Cortijo J, et al. Among authors: hatzelmann a. Br J Pharmacol. 2009 Feb;156(3):534-44. doi: 10.1111/j.1476-5381.2008.00041.x. Br J Pharmacol. 2009. PMID: 19154443 Free PMC article.

8

Pharmacology, clinical efficacy, and tolerability of phosphodiesterase-4 inhibitors: impact of human pharmacokinetics.

Tenor H, Hatzelmann A, Beume R, Lahu G, Zech K, Bethke TD. Tenor H, et al. Among authors: hatzelmann a. Handb Exp Pharmacol. 2011;(204):85-119. doi: 10.1007/978-3-642-17969-3_3. Handb Exp Pharmacol. 2011. PMID: 21695636 Review.

9

Differential effects of non-selective and selective phosphodiesterase inhibitors on human eosinophil functions.

Hatzelmann A, Tenor H, Schudt C. Hatzelmann A, et al. Br J Pharmacol. 1995 Feb;114(4):821-31. doi: 10.1111/j.1476-5381.1995.tb13278.x. Br J Pharmacol. 1995. PMID: 7539697 Free PMC article.

10

Phosphodiesterase isoenzyme families in human osteoarthritis chondrocytes--functional importance of phosphodiesterase 4.

Tenor H, Hedbom E, Häuselmann HJ, Schudt C, Hatzelmann A. Tenor H, et al. Among authors: hatzelmann a. Br J Pharmacol. 2002 Feb;135(3):609-18. doi: 10.1038/sj.bjp.0704480. Br J Pharmacol. 2002. PMID: 11834608 Free PMC article.

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