Zheng W - Search Results

1

A multiplex calcium assay for identification of GPCR agonists and antagonists.

Liu K, Southall N, Titus SA, Inglese J, Eskay RL, Shinn P, Austin CP, Heilig MA, Zheng W. Liu K, et al. Among authors: zheng w. Assay Drug Dev Technol. 2010 Jun;8(3):367-79. doi: 10.1089/adt.2009.0245. Assay Drug Dev Technol. 2010. PMID: 20230302 Free PMC article.

2

A 1536-well cAMP assay for Gs- and Gi-coupled receptors using enzyme fragmentation complementation.

Weber M, Ferrer M, Zheng W, Inglese J, Strulovici B, Kunapuli P. Weber M, et al. Among authors: zheng w. Assay Drug Dev Technol. 2004 Feb;2(1):39-49. doi: 10.1089/154065804322966306. Assay Drug Dev Technol. 2004. PMID: 15090209

3

High throughput assay technologies for ion channel drug discovery.

Zheng W, Spencer RH, Kiss L. Zheng W, et al. Assay Drug Dev Technol. 2004 Oct;2(5):543-52. doi: 10.1089/adt.2004.2.543. Assay Drug Dev Technol. 2004. PMID: 15671652 Review.

4

Application of division arrest technology to cell-based HTS: comparison with frozen and fresh cells.

Kunapuli P, Zheng W, Weber M, Solly K, Mull R, Platchek M, Cong M, Zhong Z, Strulovici B. Kunapuli P, et al. Among authors: zheng w. Assay Drug Dev Technol. 2005 Feb;3(1):17-26. doi: 10.1089/adt.2005.3.17. Assay Drug Dev Technol. 2005. PMID: 15798392

5

A short-incubation reporter-gene assay for high-throughput screening of estrogen receptor-alpha antagonists.

Shi X, Zheng W, Schneeweis JE, Fischer PA, Strulovici B, Peekhaus NT. Shi X, et al. Among authors: zheng w. Assay Drug Dev Technol. 2005 Aug;3(4):393-400. doi: 10.1089/adt.2005.3.393. Assay Drug Dev Technol. 2005. PMID: 16180994

6

Quantitative high-throughput screening: a titration-based approach that efficiently identifies biological activities in large chemical libraries.

Inglese J, Auld DS, Jadhav A, Johnson RL, Simeonov A, Yasgar A, Zheng W, Austin CP. Inglese J, et al. Among authors: zheng w. Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11473-8. doi: 10.1073/pnas.0604348103. Epub 2006 Jul 24. Proc Natl Acad Sci U S A. 2006. PMID: 16864780 Free PMC article.

7

Fluorescent protein-based cellular assays analyzed by laser-scanning microplate cytometry in 1536-well plate format.

Auld DS, Johnson RL, Zhang YQ, Veith H, Jadhav A, Yasgar A, Simeonov A, Zheng W, Martinez ED, Westwick JK, Austin CP, Inglese J. Auld DS, et al. Among authors: zheng w. Methods Enzymol. 2006;414:566-89. doi: 10.1016/S0076-6879(06)14029-X. Methods Enzymol. 2006. PMID: 17110211

8

High-throughput screening assays for the identification of chemical probes.

Inglese J, Johnson RL, Simeonov A, Xia M, Zheng W, Austin CP, Auld DS. Inglese J, et al. Among authors: zheng w. Nat Chem Biol. 2007 Aug;3(8):466-79. doi: 10.1038/nchembio.2007.17. Nat Chem Biol. 2007. PMID: 17637779 Review.

9

Three classes of glucocerebrosidase inhibitors identified by quantitative high-throughput screening are chaperone leads for Gaucher disease.

Zheng W, Padia J, Urban DJ, Jadhav A, Goker-Alpan O, Simeonov A, Goldin E, Auld D, LaMarca ME, Inglese J, Austin CP, Sidransky E. Zheng W, et al. Proc Natl Acad Sci U S A. 2007 Aug 7;104(32):13192-7. doi: 10.1073/pnas.0705637104. Epub 2007 Aug 1. Proc Natl Acad Sci U S A. 2007. PMID: 17670938 Free PMC article.

10

N4-phenyl modifications of N2-(2-hydroxyl)ethyl-6-(pyrrolidin-1-yl)-1,3,5-triazine-2,4-diamines enhance glucocerebrosidase inhibition by small molecules with potential as chemical chaperones for Gaucher disease.

Huang W, Zheng W, Urban DJ, Inglese J, Sidransky E, Austin CP, Thomas CJ. Huang W, et al. Among authors: zheng w. Bioorg Med Chem Lett. 2007 Nov 1;17(21):5783-9. doi: 10.1016/j.bmcl.2007.08.050. Epub 2007 Aug 28. Bioorg Med Chem Lett. 2007. PMID: 17827006 Free PMC article.

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