Lansbury PT - Search Results

1

Improving binding specificity of pharmacological chaperones that target mutant superoxide dismutase-1 linked to familial amyotrophic lateral sclerosis using computational methods.

Nowak RJ, Cuny GD, Choi S, Lansbury PT, Ray SS. Nowak RJ, et al. Among authors: lansbury pt. J Med Chem. 2010 Apr 8;53(7):2709-18. doi: 10.1021/jm901062p. J Med Chem. 2010. PMID: 20232802 Free PMC article.

2

An intersubunit disulfide bond prevents in vitro aggregation of a superoxide dismutase-1 mutant linked to familial amytrophic lateral sclerosis.

Ray SS, Nowak RJ, Strokovich K, Brown RH Jr, Walz T, Lansbury PT Jr. Ray SS, et al. Among authors: lansbury pt jr. Biochemistry. 2004 May 4;43(17):4899-905. doi: 10.1021/bi030246r. Biochemistry. 2004. PMID: 15109247

3

Small-molecule-mediated stabilization of familial amyotrophic lateral sclerosis-linked superoxide dismutase mutants against unfolding and aggregation.

Ray SS, Nowak RJ, Brown RH Jr, Lansbury PT Jr. Ray SS, et al. Among authors: lansbury pt jr. Proc Natl Acad Sci U S A. 2005 Mar 8;102(10):3639-44. doi: 10.1073/pnas.0408277102. Epub 2005 Feb 28. Proc Natl Acad Sci U S A. 2005. PMID: 15738401 Free PMC article.

4

A possible therapeutic target for Lou Gehrig's disease.

Ray SS, Lansbury PT Jr. Ray SS, et al. Among authors: lansbury pt jr. Proc Natl Acad Sci U S A. 2004 Apr 20;101(16):5701-2. doi: 10.1073/pnas.0401934101. Epub 2004 Apr 12. Proc Natl Acad Sci U S A. 2004. PMID: 15079068 Free PMC article. No abstract available.

5

Design, Synthesis, and Biological Evaluation of a Series of Oxazolone Carboxamides as a Novel Class of Acid Ceramidase Inhibitors.

Caputo S, Di Martino S, Cilibrasi V, Tardia P, Mazzonna M, Russo D, Penna I, Summa M, Bertozzi SM, Realini N, Margaroli N, Migliore M, Ottonello G, Liu M, Lansbury P, Armirotti A, Bertorelli R, Ray SS, Skerlj R, Scarpelli R. Caputo S, et al. J Med Chem. 2020 Dec 24;63(24):15821-15851. doi: 10.1021/acs.jmedchem.0c01561. Epub 2020 Dec 8. J Med Chem. 2020. PMID: 33290061 Free PMC article.

6

Protofibrillar islet amyloid polypeptide permeabilizes synthetic vesicles by a pore-like mechanism that may be relevant to type II diabetes.

Anguiano M, Nowak RJ, Lansbury PT Jr. Anguiano M, et al. Among authors: lansbury pt jr. Biochemistry. 2002 Sep 24;41(38):11338-43. doi: 10.1021/bi020314u. Biochemistry. 2002. PMID: 12234175

7

Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line.

Liu Y, Lashuel HA, Choi S, Xing X, Case A, Ni J, Yeh LA, Cuny GD, Stein RL, Lansbury PT Jr. Liu Y, et al. Among authors: lansbury pt jr. Chem Biol. 2003 Sep;10(9):837-46. doi: 10.1016/j.chembiol.2003.08.010. Chem Biol. 2003. PMID: 14522054

8

Alpha-synuclein, especially the Parkinson's disease-associated mutants, forms pore-like annular and tubular protofibrils.

Lashuel HA, Petre BM, Wall J, Simon M, Nowak RJ, Walz T, Lansbury PT Jr. Lashuel HA, et al. Among authors: lansbury pt jr. J Mol Biol. 2002 Oct 4;322(5):1089-102. doi: 10.1016/s0022-2836(02)00735-0. J Mol Biol. 2002. PMID: 12367530

9

Structural basis for conformational plasticity of the Parkinson's disease-associated ubiquitin hydrolase UCH-L1.

Das C, Hoang QQ, Kreinbring CA, Luchansky SJ, Meray RK, Ray SS, Lansbury PT, Ringe D, Petsko GA. Das C, et al. Among authors: lansbury pt. Proc Natl Acad Sci U S A. 2006 Mar 21;103(12):4675-80. doi: 10.1073/pnas.0510403103. Epub 2006 Mar 13. Proc Natl Acad Sci U S A. 2006. PMID: 16537382 Free PMC article.

10

Synthesis and amyloid binding properties of rhenium complexes: preliminary progress toward a reagent for SPECT imaging of Alzheimer's disease brain.

Zhen W, Han H, Anguiano M, Lemere CA, Cho CG, Lansbury PT Jr. Zhen W, et al. Among authors: lansbury pt jr. J Med Chem. 1999 Jul 29;42(15):2805-15. doi: 10.1021/jm990103w. J Med Chem. 1999. PMID: 10425090

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